T-CELL RECEPTOR 의 SPLICE JUNCTION 과 SNRNA 의 BASE-PAIRING = BASE-PAIRING BETWEEN THE SPLICE JUNCTION SE- QUENCES OF T-CELL RECEPTOR GENES AND SNRNAS

다국어 초록 (Multilingual Abstract)

The Study of T-cell receptor(TCR) genes can provide clinically important information. For example, the rearrangement of TCR genes can be used as a useful marker of clonality in T-cell proliferative disorders and, as a target for immune therapy (neoplasias and autoimmune diseases). Our approach to address these issues has been to determine the structure and polymorphism of TCR α, β and γ-chain genes. Based on the analysis of splice junctions of these genes, we found extensive base-pairing between the 5' splice site(ss) sequence and U1. However, the branch site sequence, TACTAAC, and base-pairing between the 3'ss sequence and U5 have not been found.