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부가정보

국문 초록 (Abstract)

1-(2-carbomethoxyacryloyl)-5-fluorouracil (CMAFU) 을 trans-β-carbomethoxyacryl chloride 와 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine으로부터 합성하고, CMAFU와 메틸메타크릴레이트를 cyclohexanone을 용매로 사용하여 60℃ 에서 라디칼공중합을 하였다. 5-FU, CMAFU 및 poly(CMAFU-Co-MMA)들이 노랑초파리에 미치는 생리유전학적 영향을 Lewis와 Bacher 방법에 의하여 조사한 결과, CMAFU와 그 중합체가 5-FU 보다 생리유전학적 영향이 약함을 알 수 있었다.

다국어 초록 (Multilingual Abstract)

The monomer, 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) was synthesized from trans-β-carbomethoxyacryl chloride and 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine. A copolymer of CMAFU with methyl methacrylate (MMA) [poly(CMAFU-co-MMA)］ was also prepared with 2, 2`-azobisisobutyronitrile in cyclohexanone at 60 ℃. Physiological genetic effects of 5-fluorouracil(5-FU), CMAFU and poly(CMAFU-co-MMA) on Drosophila melanogaster were investigated by the adult feeding method of Lewis and Bacher. It was found that a physiological genetic effect on the Drosophile melanogaster was considerably weaker for CMAFU and its copolymer than 5-FU.