Correlation Between Serum Vitamin D Level and the Severity of Atopic Dermatitis Associated With Food Sensitization

다국어 초록 (Multilingual Abstract)

Purpose: A growing body of literature has linked vitamin D deficiency with allergic diseases, particularly atopic dermatitis (AD). In this study, weinvestigated the association between serum vitamin D status and the clinical manifestation of AD. We also developed an analytical method for thesimultaneous determination of 25-hydroxy vitamin D3 (25(OH)D3), using liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS). Methods: This study included 157 patients (79 males and 78 females) with AD, aged 4 months to 56 years. We evaluated disease severityusing the SCORing Atopic Dermatitis (SCORAD) index. Serum levels of 25(OH)D3 were determined by LC coupled with MS/MS. Total IgE and specificIgE levels were assayed using the immunoCAP system. ANOVA was used for statistical evaluation. Results: We found mild, moderate, and severeAD in 30 (11.1%), 87 (55.4%), and 40 (25.5%) patients, respectively. There was no significant correlation between serum levels of 25(OH)D3 andAD severity. However, among the 36 patients with food sensitization, the mean±SD serum levels of 25(OH)D3 were significantly higher (P<0.05) inpatients with mild disease (21.2±5.18 ng/mL) compared with the levels in patients with moderate (17.9±4.02 ng/mL) or severe AD (13.3±5.11ng/mL) disease. Conclusions: These results suggest that vitamin D deficiency is related to the severity of AD associated with food sensitization.
Thus, these data suggest a role for vitamin D in a select group of AD patients.

참고문헌 (Reference)

1 Ehlayel MS, "s high prevalence of vitamin D deficiency evidence for asthma and allergy risks" 43 : 81-88, 2011

2 Sharief S, "Vitamin D levels and food and environmental allergies in the United States: results from the National Health and Nutrition Examination Survey 2005-2006" 127 : 1195-1202, 2011

3 Chi A, "Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the urban environment and childhood asthma study" 41 : 842-850, 2011

4 Liu PT, "Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response" 311 : 1770-1773, 2006

5 Benson AA, "The role of vitamin D in the immunopathogenesis of allergic skin diseases" 67 : 296-301, 2012

6 Vassallo MF, "Season of birth and food allergy in children" 104 : 307-313, 2010

7 Camargo CA, "Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D" 120 : 131-136, 2007

8 Sidbury R, "Randomized controlled trial of vitamin D supplementation for winter-related atopic dermatitis in Boston: a pilot study" 159 : 245-247, 2008

9 Gale CR, "Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and child outcomes" 62 : 68-77, 2008

10 Camargo CA, "Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age" 85 : 788-795, 2007

11 Hyppönen E, "Infant vitamin D supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966" 1037 : 84-95, 2004

12 Liu X, "Gene-vitamin D interactions on food sensitization: a prospective birth cohort study" 66 : 1442-1448, 2011

13 Veldman CM, "Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system" 374 : 334-338, 2000

14 Hanifin JM, "Diagnostic features of atopic dermatitis" 92 : 44-47, 1980

15 Greer FR, "Defining vitamin D deficiency in children: beyond 25-OH vitamin D serum concentrations" 124 : 1471-1473, 2009

16 Wang TT, "Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression" 173 : 2909-2912, 2004

17 Department for Environment, Food and Rural Affairs, "Consumption of selected household foods (GB) 1942 to 2000 [Internet]" HMSO

18 Poon AH, "Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy" 170 : 967-973, 2004

19 Keet CA, "Age- and atopy-dependent effects of vitamin D on wheeze and asthma" 128 : 414-416, 2011

20 Hata TR, "Administration of oral vitamin D induces cathelicidin production in atopic individuals" 122 : 829-831, 2008