Meprobamate Chlorpromazine 및 電擊療法이 白鼠의 Estrous Cycle에 미치는 影響 = EFFECT OF MEPROBAMATE, CHLORPROMAZINE AND EST ON THE ESTROUS CYCLES IN THE ALBINO RAT

다국어 초록 (Multilingual Abstract)

The cyclical activity of the Sprague-Dawley strain rat was observed under the various conditions of administration of meprobamate, chlorpromazine and EST, using the vaginal smear technique.
The experimental groups were as followings;
GroupⅠ Normal control rats
GroupⅡ Rats administered with meprobamate in doses of 60㎎/㎏/day
GroupⅢ Rats administered with meprobamate in doses of 400㎎/㎏/day
GroupⅣ Rats administered with meprobamate in doses of 400㎎/㎏/day and
chlorpromazine, 20㎎/㎏/day
GroupⅤ Rats administered with meprobamate in doses of 60㎎/㎏/day and
chlorpromazine, 20㎎/㎏/day
GroupⅥ Rats administered with meprobamate in doses of 60㎎/㎏/day and
chlorpromazine, 5㎎/㎏/day
GroupⅦ Rats administered with meprobamate in doses of 60-400㎎/㎏/day combined with EST.
In Group Ⅱ and Ⅲ, the average length of the estrous cycle was 9.64 and 10.02 days, which revealed the significant prolongation in comparison with 4.9 days in the normals. Group Ⅳ and Ⅴ showed complete cessation of estrous state of the cycle. Group Ⅵ had irregular cyclical activity, showing 14.4 days interval of the cycle. Group Ⅶ had complete cessation of estrous stage of the cycle immediately after EST.
It seems significant that meprobamate has an effect on the cyclical activity of the estrous cycle, which is increased if combined with chlorpromazine or EST.