l-Ethyl-6-fluoro-l, 4-dihydro-4-oxo-7-(1-piperaziny1) quinolinea-3-carboxylic acid-dextran was synthesized by the reaction of l-ethyl-6-fluoro-l, 4-dihydro -4-oxo-7(1-piperaziny1)quino1ine-3-acry1oy1 chloride with dextran. Polymeric drug was tested fo...
l-Ethyl-6-fluoro-l, 4-dihydro-4-oxo-7-(1-piperaziny1) quinolinea-3-carboxylic acid-dextran was synthesized by the reaction of l-ethyl-6-fluoro-l, 4-dihydro -4-oxo-7(1-piperaziny1)quino1ine-3-acry1oy1 chloride with dextran. Polymeric drug was tested for antimicrobial activity in vitro against ten species of microorganisms. Polymeric drug revealed good antibacterial activity against Bacillus subtillis ATCC 6633, Staphyloccus aureus ATCC 25923, Mycrobactenum phlei IFO 3158, Salmonella typhimui-ium KCTC 1925, Eschenchia coli KCTC 1039, Escherichia coli ESS, Klebsiella Pueumouiae KCTC 1560 and Pseudomonas aeruginosa IFO 13130. Polymeric drug have no antimicrobial against Candida albicans ATCC 10231, but moderately active Micrococcus luteus ATCC 9341.