만성 B형 간염 환자의 간조직내 HBs Ag 및 HBc Ag 출현에 관한 면역조직화학적 연구 = An Immunohistochemical Study of Hepatitis B Antigen Surface (HBs Ag) and Hepatitis B Core Antigen (HBc Ag) in the Liver with Chronic Hepatitis B.

다국어 초록 (Multilingual Abstract)

To evaluate correlation of HBs Ag and HBc Ag in the liver with histologic activity and diagnostic implication, the author has investigated expression patterns of HBs Ag and HBc Ag in 88 biopsied liver tissue from chronic hepatitis B. with indirect immunohistochemical method HBs Ag and HBc Ag were detected and classified as focal, patchy and diffuse patterns. The above results were compared with several serologic profiles and histologic activity which was arbitrarily established.
The results are as followings.
1. HBs Ag in the liver was dectected in 97％ and HBc in 72％, HBc Ag was found in the nucleus (47％) or in the cytoplasm (48％) or in both (33％).
2. Comparing to several serologic profiles, HBs Ag in the liver tissue was detected in 97％ Of the cases with seropositive HBs Ag and HBe Ag, with expression patterns of focal 36％, patchy 28％ And diffuse 34％.
In cases with seropositive HBs Ag and Anti-HBe Ab, HBs Ag in the liver tissue was detected in 100％ With patterns of focal 67％, patchy 16.5％ and diffuse 16.5％, and in cases with seropositive HBs Ag and Anti-HBe Ab, HBs Ag in the liver tissue was noted in 90% With patterns of focal 30％, patchy 40％ And diffuse 20％.
3. Comparing several serologic profiles, HBc Ag in the nucleus was detected in 53％ With seropostive HBs Ag and HBe Ag and Anti-HBs Ab, nuclear HBc Ag was noted in 40％, with patterns of focal 30％ And patchy 10％.
4. HBs Ag in the liver according to histologic activity showed 98％ In grade Ⅰ, with patterns of focal 40％, patchy 28％ And diffuse 30％, In grade Ⅱ HBs Ag in the liver was detected in 94％, with patterns of focal 55％, patchy 27％ And diffuse 13％ And in grade Ⅲ HBs Ag in the liver showed 95％ With patterns of focal 22％, patchy 30％ And diffuse 43％.
5. HBc Ag in the nucleus according to histologic activity showed in 44％ in grade Ⅰ, with expression patterns of focal 21％, patchy 18％ And diffuse 5％. In grade Ⅱ HBc Ag was detected in 45％ With patterns of focal 31％, patchy 5％ And diffuse 9％ And in grade Ⅲ, HBc Ag was detected in 52％ With patterns of focal 48％, patchy 4％ And diffuse 0％.
With above results, it is thought that HBg Ag in the liver is signficantly reated with HBs Ag antigenemia and HBc Ag in the liver is colosely related with serum HBe Ag or Anti-HBe Ab in chronic hepatitis B.
The expression patterns of HBs Ag and HBc Ag in the liver are so variable that they could not access the diagnostic implication.
But in chronic active hepatitis, the more abundant HBs Ag in the liver, the more histologic activity is found, in contrary the more abundant HBc Ag in the liver, the less histologic activity is noted.