Flexible Anti-Pathogenic Patch Composed of Vertically Aligned Nanospike Arrays for Regulating Stem Cell Behavior

다국어 초록 (Multilingual Abstract)

Aligned nanotopography including nanopattern, nanoneedle, and nanowire hold strong potential to regulate stem cell behaviors. In this study, we present a highly flexible hydrogel nanospike array as a precisely defined, vertically aligned polymeric platform for enhancing the differentiation of stem cells and efficiently suppressing biofilm. This vertical nanostructure not only imposes a strong physical stimulus to the cells but also leads to a three-dimensional spherical morphology of the cells, which remarkably promotes their osteogenic differentiation and secretion of growth factors. At the same time, it shows efficient biofilm resistance. This multifunctional flexible hydrogel platform with its vertical nanoarchitectures can be used as transplantable stem cell scaffold or biomedical implant with enhanced stem cell and anti-pathogenic functions.