C 형 만성 간질환 환자에서 혈청 Alanine Aminotransferase 치와 혈청 C 형 간염 바이러스 개체수와의 관계 = The Correlation between Serum Alanine Aminotransferase Levels and Serum HCV RNA Levels in Hepatitis C Virus - related Chronic Liver Disease

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Objectives: We studied the correlation between HCV RNA titer and level of log(ALT) in chronic hepatitis C to know the pathogenetic role of HCV, using heminested reverse transcription-polymerase chain reaction and end point dilution method with standard internal control HNA. Methods: Fifty-two patients with chronic hepatitis C were enrolled and their serum HCV RNA were detected by heminested reverse transcription-polymerase chain reaction and serum HCV RNA concentrations were quantitated by end point dilution method using mutated HCV RNA molecule as a standard internal control. Results: 1) Detection limit of HCV RNA titer by our heminested RT-PCR method was 10'copies/ml. 2) HCV RNA was detected in the sera of 31patients with chronic hepatitis C(59.6%) 3) The serum HCV RNA concentration showed wide range of distribution from 10(3) to 10(11)copies/ml. 4) There was no significant correlation bet ween HCV RNA titer and level of log(ALT). Conclusion: This suggests that the direct cytopathic effect of HC:V, if present, is less likely to be the main mechanism of liver injury in chronic hepatitis C.