To clarify the effect of sucralfate on glycoprotein and somatostatin, this study was performed with the use of Wistar rat and measuring the concentration of glycoprotein and somatostatin, using radioimmunoassay kits. The result were as follows; 1) In ...
To clarify the effect of sucralfate on glycoprotein and somatostatin, this study was performed with the use of Wistar rat and measuring the concentration of glycoprotein and somatostatin, using radioimmunoassay kits. The result were as follows; 1) In determination of ulcer index, there could be showed the increase in the sucralfate group as compared with the ulcer group (2.20+-1.94, p<0.01). In gastric pH, there could be demonstrated the ulcer group as compared with the control group. 2) In determination of Alcian blue-binding protein of soluble mucus, there could be demonstrated the increase in the sucralfate group as compared with the ulcer group (0.23+-0.07 mg/5 ml, 0.67+-0.03 mg/5 ml, p < 0.05). 3) The concentration of plasma somatostatin revealed the increase in the sucralfate group as compared with the ulcer group and control group (p<0.001). 4) The concentration of somatostatin of gastric juice revealed the increase in the sucralfate group and the ulcer group as compared with the control group respectively (p<0.001). 5) The concentration of somatostatin of gastric mucosa revealed the increase in the sucralfate group as compared with the control group and the ulcer group respectively (p<0.001, p<0.01).