은나노입자의 방사성 동위원소 운반체 적용 유효성 검증 연구 = Feasibility Study on Silver Nanoparticle Application to a Radioisotope Carrier

다국어 초록 (Multilingual Abstract)

In this study, an Ag-polyaniline-silica (Ag-PANI-silica) nanoparticle was evaluated asa radioisotope carrier. An Ag-PANI-silica nanoparticle was incubated in the 125I solution for aduration of 24 hr to test its radioisotope absorptivity. During the incubation, radioactivity of thenanoparticle was measured at 3, 6, 12, and 24 hr. After a 24 hr incubation, 125I-Ag-PANI-silicananoparticle was incubated in a fresh saline for a duration of 48 hr to check its stability. Additionally,the 125I-Ag-PANI-silica nanoparticle was injected to the ICR mouse to investigate its in-vivodistribution characteristics. The 125I absorption yield of the Ag-PANI-silica nanoparticle was higherthan 95% after a 6 hr incubation period in the 125I solution. And 125I-Ag-PANI-silica was stablefor 48 hr at 80% yield at room temperature. The SPECT/CT image of a mouse that received 125IAg-PANI-silica complex showed that the 125I-Ag-PANI-silica complex was distributed in the lung,stomach and thyroid at 30 min post injection. From these results, the Ag-PANI-silica nanoparticlehas good radio-iodine carrying property and can be applicable for the purpose of diagnosis andtherapy.