Expression of CYLD and NF- <i>κ</i> B in Human Cholesteatoma Epithelium

다국어 초록 (Multilingual Abstract)

<P>The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-<I>κ</I>B, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-<I>κ</I>B signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-<I>κ</I>B in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In cholesteatoma epithelium, activated NF-<I>κ</I> B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (<I>P</I> < .05). Furthermore, a significant inverse correlation was detected between CYLD and activated NF-<I>κ</I>B expression in cholesteatoma epithelium (<I>r</I> = −0.630). We found that CYLD reduced and activated increased NF-<I>κ</I>B in cholesteatoma epithelium in comparison to RA skin. The inverse correlation between CYLD and activated NF-<I>κ</I>B in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia.</P>