국내 돼지 유산태아에서 원인 바이러스 검출과 유병률 조사 = Detection and prevalence of viral pathogens from aborted fetuses and stillborn piglets in Korea

다국어 초록 (Multilingual Abstract)

This experiment was conducted to investigate the presence of recognized abortifacient viruses from aborted fetuses and stillborn piglets in cases of reproductive failure in sows by PCR. A total of 219 samples of aborted fetuses or stillborn piglets, submitted to the School of Veterinary Medicine of Kangwon National University between 2006 and 2009 May, were collected from 5 provinces in Korea. Abortifacient virus infections were detected in 82 (37.4%) out of 219 aborted fetuses or stillborn piglets as well as on 39 (40.2%) out of 97 pig farms. The major viral infections were porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV) and Aujesky`s disease virus (ADV) for which 46 (21%), 19 (8.6%) and 16 (7.3%) were positive, respectively, with 9 fetuses had complicated infection of PCV2＋PRRSV or ADV or both. And 8 (3.6%) for SIV, 3 (1.3%) for PPV and 1 (0.4%) for JEV were positive as minor viral infection. The results suggest that PCV2, PRRSV, ADV is apparently the most important viral infectious agents associated with fetal infection leading to abortion or stillbirth in Korea. SIV, PPV and JEV might have a minor impact on reproductive disease.

참고문헌 (Reference)

1 박최규, "혈청학적 분석을 통한 돼지 생식기호흡기증후군의 농장단위 감염유형" 대한수의학회 48 (48): 67-73, 2008

2 박최규, "우리나라 양돈장의 예방 접종 실태 조사" 31 (31): 257-264, 2007

3 Pensaert MB, "Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection" 98 (98): 175-183, 2004

4 Bachmann PA, "Swine Influenza Virus, In Virus Infections of Porcines, vol. 2" Elsevier Science Publishers BV 193-207, 1989

5 Mateusen B, "Susceptibility of pig embryos to porcine circovirus type 2 infection" 61 (61): 91-101, 2004

6 Kim BH, "Studies on Aujeszky's disease in Korea, 2; restriction endonuclease analysis of Aujeszky's disease virus genomes isolated from piglets in Korea" 30 (30): 37-41, 1988

7 Christianson WT, "Stillbirths, mummies, abortions, and early embryonic death" 8 (8): 623-639, 1992

8 Pascua PN, "Seroprevalence and genetic evolutions of swine influenza viruses under vaccination pressure in Korean swine herds" 138 (138): 43-49, 2008

9 Nielsen HS, "Reversion of a live porcinereproductive and respiratory syndrome virus vaccine investigated by parallel mutations" 82 (82): 1263-1272, 2001

10 Kluge JP, "Psedurabies (Aujeszky's disease), In Disease of Swine. 7th ed" Iowa State Univiersity Press 312-323, 1992

11 유광수, "Prevalence of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2 and porcine parvovirus from aborted fetuses and pigs with respiratory problems in Korea." Korean Society of Veterinary Science 2 (2): 201-207, 200112

12 Kim J, "Prevalence of porcine circovirus type 2 in aborted fetuses and stillborn piglets" 155 (155): 489-492, 2004

13 Segalés J, "Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review" 24 (24): 109-124, 2002

14 Sanchez RE Jr, "Porcine circovirus 2 infection in swine fetuses inoculated at different stages of gestation" 83 (83): 169-176, 2001

15 Segalés J, "Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease" 98 (98): 137-149, 2004

16 West KH, "Myocarditis and abortion associated with intra-uterine infection of sows with porcine circovirus 2" 11 (11): 530-532, 1999

17 Allende R, "Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype" 145 (145): 1149-1161, 2000

18 O'Connor B, "Multiple porcine circovirus 2-associated abortions and reproductive failure in a multisite swine production unit" 42 (42): 551-553, 2001

19 Wolf VH, "Molecular basis for porcine parvovirus detection in dead fetuses" 7 (7): 509-517, 2008

20 Vannier P, "Infectious causes of abortion in swine" 34 (34): 367-376, 1999

21 Maldonado J, "Identification of viral pathogens in aborted fetuses and stillborn piglets from cases of swine reproductive failure in Spain" 169 (169): 454-456, 2005

22 Wesley RD, "Exposure of sero-positive gilts to swine influenza virus may cause a few stillbirths per litter" 68 (68): 215-217, 2004

23 Nielsen J, "Experimental inoculation of late term pregnant sows with a field isolate of porcine reproductive and respiratory syndrome vaccine-derived virus" 84 (84): 1-13, 2002

24 Albina E, "Epidemiology of porcine reproductive and respiratory syndrome (PRRS): An overview" 55 (55): 309-316, 1997

25 Straw BE, "Differential diagnosis of swine diseases, In Diseases of Swine, 8th ed" Iowa State University Press 41-89, 1999

26 Holler LD, "Diagnosis of swine abortion" 2 (2): 29-31, 1994

27 Soares RM, "Detection of prcine parvovirus DNA by the polymerase chain reactions DNA using primers to the highly conserved nonstructural protein gene, NS-1" 78 (78): 191-198, 1999

28 Sanchez RE Jr, "Characteristics of porcine circovirus-2 replication in lymphoid organs of pigs inoculated in late gestation or postnatally and possible relation to clinical and pathological outcome of infection" 16 (16): 175-185, 2004

29 Sanchez RE Jr, "Change of porcine circovirus 2 target cells in pigs during development from fetal to early postnatal life" 9 (9): 15-25, 2003

30 Park JS, "Birth abnormalities in pregnant sows infected intranasally with porcine circovirus 2" ELSEVIER SCI LTD 132 (132): 139-144, 200502