Endoscopic Ultrasound-Guided Fine Needle Aspiration in Submucosal Lesion

다국어 초록 (Multilingual Abstract)

A submucosal lesion, more appropriately a subepithelial lesion, is hard to diagnose. Endoscopic ultrasonography is good to differentiate the nature of submucosal lesion. For definite diagnosis, tissue acquisition from submucosal lesion is necessary, and many methods have been introduced for this purpose mainly by endoscopic ultrasonography, such as endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), EUS-guided Trucut Biopsy (TCB), and EUS-guided fine needle biopsy (FNB). For EUS-FNA, adequate processing of specimen is important, and for proper diagnosis of EUS-FNA specimen, both cytologic and histologic examinations, including immunohistochemical stains, are important. All gastrointestinal stromal tumors have some degree of malignant potential, so there have been a lot of efforts and methods to increase diagnostic yields of submucosal lesion. We herein review the current hot topics on EUS-FNA for submucosal tumor, such as needles, on-site cytopathologists, immunohistochemical stains, EUS-TCB, EUS-FNB, Ki-67 labelling index, DOG1, and combining EUS-FNA and EUS-TCB.

참고문헌 (Reference)

1 Landi B, "The role of endosonography in submucosal tumours" 23 : 679-701, 2009

2 Ando N, "The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis" 55 : 37-43, 2002

3 Sato T, "Strategy of treatment of submucosal gastric tumors" 10 : 292-295, 2005

4 Akahoshi K, "Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration" 13 : 2077-2082, 2007

5 Polkowski M, "Learning, techniques, and complications of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) technical guideline" 44 : 190-206, 2012

6 Dumonceau JM, "Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline" 43 : 897-912, 2011

7 Mazur MT, "Gastric stromal tumors: reappraisal of histogenesis" 7 : 507-519, 1983

8 Iglesias-Garcia J, "Feasibility and yield of a new EUS histology needle: results from a multicenter, pooled, cohort study" 73 : 1189-1196, 2011

9 Erickson RA, "Factors predicting the number of EUS-guided fine-needle passes for diagnosis of pancreatic malignancies" 51 : 184-190, 2000

10 Suzuki T, "Factors associated with inadequate tissue yield in EUS-FNA for gastric SMT" 2011 : 619128-, 2011

11 Okubo K, "Endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of gastrointestinal stromal tumors in the stomach" 39 : 747-753, 2004

12 Chatzipantelis P, "Endoscopic ultrasound-guided fine needle aspiration biopsy in the diagnosis of gastrointestinal stromal tumors of the stomach: a study of 17 cases" 17 : 15-20, 2008

13 Zhang S, "Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA): experience of an academic centre in the USA" 21 : 35-43, 2010

14 Sa˘ftoiu A, "Endoscopic ultrasound (EUS)-guided Trucut biopsy adds significant information to EUS-guided fine-needle aspiration in selected patients: a prospective study" 42 : 117-125, 2007

15 Turhan N, "Endoscopic ultrasonography-guided fine-needle aspiration for diagnosing upper gastrointestinal submucosal lesions: a prospective study of 50 cases" 39 : 808-817, 2011

16 Vilmann P, "Endoscopic ultrasonography with guided fine needle aspiration biopsy in pancreatic disease" 38 : 172-173, 1992

17 Papanikolaou IS, "Endoscopic ultrasonography for gastric submucosal lesions" 3 : 86-94, 2011

18 Hoda KM, "EUS-guided sampling of suspected GI stromal tumors" 69 : 1218-1223, 2009

19 Mekky MA, "Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors" 71 : 913-919, 2010

20 Yoshida S, "Diagnostic findings of ultrasound-guided fine-needle aspiration cytology for gastrointestinal stromal tumors: proposal of a combined cytology with newly defined features and histology diagnosis" 59 : 712-719, 2009

21 지정선, "Diagnostic Yield of Tissue Sampling Using a Bite-On-Bite Technique for Incidental Subepithelial Lesions" 대한내과학회 24 (24): 101-105, 2009

22 Sakamoto H, "Diagnosis of subepithelial tumors in the upper gastrointestinal tract by endoscopic ultrasonography" 2 : 289-297, 2010

23 Fu K, "Diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration biopsy: a potential pitfall" 6 : 294-301, 2002

24 Hwang DG, "DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks" 135 : 448-453, 2011

25 Kida M, "Comparison of diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration with 22- and 25-gauge needles in the same patients" 1 : 102-107, 2011

26 Nishida T, "Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version" 13 : 416-430, 2008

27 Varadarajulu S, "Best practices in endoscopic ultrasound-guided fine-needle aspiration" 1 : 2012

28 Storch I, "Advantage of EUS Trucut biopsy combined with fine-needle aspiration without immediate on-site cytopathologic examination" 64 : 505-511, 2006

29 Rösch T, "Accuracy of endoscopic ultrasonography in upper gastrointestinal submucosal lesions: a prospective multicenter study" 37 : 856-862, 2002

30 Hunt GC, "A comparison of EUS features between CD-117 positive GI stromal tumors and CD-117 negative GI spindle cell tumors" 57 : 469-474, 2003