鷄胎 長骨成長에 미치는 Cortisone 및 Cyclophosphamide의 響影에 關한 硏究 = Study of Effects of Cortisone and Cyclophosphamide on the Growth of the Long Bones in the Chick Embryos

다국어 초록 (Multilingual Abstract)

This study was to observe the effects of cortisone and cyclophosphmide(endoxanasta) on growth of the long bones-humerus, ulna, femur, tibiotarsus and tarsometatarsus-in the chick embryos, and also studied the relationship between the ratio of the volume of the long bones in control, cortisone & endoxan treated groups and the degree of differention in them by the discriminant function method.
The results were summarized as follows:
1. When injected with cortisone acetate, the long bones of the chick embryos were observed with remarkable growth inhibitionin in the first half of embryonal age.
2. The growth inhibition appeared to be much stronger with the group of 5mg dosage than that of 3mg dosage except tarsometatarsus, and 6th day group than 8th day group generally.
3. Endoxan also inhibited the growth of the long bones of the chick embryos in the first half of embryonal age and stronger than with the group of 0.2mg dosage than that of 0.1mg dosage generally. But endoxan of 0.lmg dosage showed no significant evidence of growth inhibition.
4. The discrimination of cortisone treated chick embryos from controlled chick emsbryos was easier than that of endoxan treated embryo from cortisone treated embryos and that of endoxan treated embryos from controlled embryos.
5. In the control and cortisone treated group, individual analysis could be discriminated by the discriminant value.