RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

The development of specific monoclonal antibodies to antigens present on all peripheral T cells(OKT 3), helper/inducer(OKT 4), and cytotoxic/ suppress(OKT 8) sudsets provides a simple means to dissect the immune cell populations.
In patients with acute hepatitis virus(HBV) infection, OKT4/OKT88 ratio are known to be lower than normal control group. However. published data on the altreation of peripheral T cell subsets in chronic hepatitis(AVH) and chronic active hepatitis(CAH). Sera from 16 patients with AVH, 18 patients with CAH and 17 normal healthy control group were assayed for the evalution of total lymphocytes, helper/inducer,cytotoxic/ suppressor sbbsets and pan B lymphocytes(OKB 7).
The resullts were as follows;
1. In patients with AVH, the value of OKT3 55.3±11.84%, OKT4 39.6±110.85%. OKB7 25.8 ±14.08%, T4/T8 ratio 1.49±0.31 were significantly decreased than normal control group that showed OKT3 66.5±10.6%, OKT4 47.2±15.02%, OKT8 25.3±7.30%, T4/T8 ratio 1.87±0.46 and OKB7 32.9 ±10.75%(p<0.05) and the value of OKT8 was not significantly different from that of normal control group.
2. In patients with CAH, OKT3 65.3±7.14%, OKB7 30.0 ±15.83%, were not significantly different from normal control group, but OKT4 30.0 ±12.69% was decreased and OKT8 37.9± 10.70% was increased than normal control group(p<0.05)
3. T-cell subset alterations during the course of AVH disclosed that OKT4 and T4/T8 ratio were decreased in early phase and gradually increased near normal level around 10 weeks later. But OKT8 was not changed significantly.
According to the above results the regulation of immune mechanism in AVH and CAH appears to be different. In AVH, the percentage of T and B cells decreased. T4/T8 ratio decreased by decrement of T4 and then gradually normalized during the recovery of illness. In CAH, the percentage of T and B cells were normal. But, OKT4 were stilllower than normal control group. Thus the role of OKT4 would be important for the recovery from AVH and CAH.