태아 대장 , 대장선종 및 대장암 환자에서 점소 당항원 Tn , sTn의 발현 = Expression of Mucin Carbohydrate Tn, sTn in Fetal Colon, Colonic Polyp, and Colon Cancer태아 대장 , 대장선종 및 대장암 환자에서 점소 당항원 Tn , sTn의 발현

다국어 초록 (Multilingual Abstract)

N/A

다국어 초록 (Multilingual Abstract)

Background/Aims: Tn, Sialosyl-Tn(sTn) mucin core carbohydrate antigens are specific for mucin-type protein-linked N-acetylgalactosamine, which are involved in early steps of 0-linked glycosylation of mucin synthesis. These antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer. Methods: We have studied that the expression of both antigens in terms of polyp cancer sequence and oncodevelopmental nature in Korean fetal and normal adult colon, colorectal polyps, transitional mucosa and carcinoma using monoclonal antibody CU l (Tn) and TKH2 (sTn) by immunohistochemical method. Results: Tn antigen was expressed in supranuclear cytoplasm of surface epithelial cells, and sialosyl-Tn antigen was in that of crypt bases and mucin lakes. Tn, sTn were expressed in 30%, 80% of 10 fetal colon, 20%, 10% of l0 normal adult colon, 8S%, 23% of l3 colon polyps and 74%, 65% of 23 transitional mucosa, 40%, and 84% of 43 colorectal adenocarcinoma respectively. Conclusions: These results suggest sTn carbohydrate antigen is a more useful tumor marker of colon cancer at tissue level and shows more specific differentiation marker in terms of polyp-cancer sequence. (Korean J Gastroenterol 1995;27:46-54)