In order to elucidate the possibility of influence on the immune system, silk peptide was administered to rats for 4 weeks. Male and female Sprague-Dawley rats were orally treated with low (500 ㎎/㎏) or high (2,000 ㎎/㎏) doses of silk peptide, a...
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https://www.riss.kr/link?id=A76198812
Jae Myun Ryu (PeerBiotech Co., Ltd.) ; Tae Myoung Kim ; Im Kwon Seo (Chungbuk National University) ; Seongho Yeon (Worldway Co., Ltd) ; Woo-Taek Lim (Worldway Co., Ltd.) ; Jeong-Yong Lee (Worldway Co., Ltd.) ; Seock-Yeon Hwang (Juseong College) ; Namgil O (Chungbuk National University) ; Jugyeong Song (Chungbuk National University) ; Jinsoo Lee (Chungbuk National University) ; Yun-Bae Kim
2008
Korean
510
KCI등재,ESCI
학술저널
361-369(9쪽)
2
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
In order to elucidate the possibility of influence on the immune system, silk peptide was administered to rats for 4 weeks. Male and female Sprague-Dawley rats were orally treated with low (500 ㎎/㎏) or high (2,000 ㎎/㎏) doses of silk peptide, a...
In order to elucidate the possibility of influence on the immune system, silk peptide was administered to rats for 4 weeks. Male and female Sprague-Dawley rats were orally treated with low (500 ㎎/㎏) or high (2,000 ㎎/㎏) doses of silk peptide, and complete blood counts, organ weights, histopathology and cellularity of immune systems were examined. Silk peptide did not cause clinical signs, although the body weight gain at the high dose was slightly reduced. In hematological analysis, the number of white blood cells (WBC) and differential counts, the number of red blood cells (RBC) and RBC indices, and the number of platelets and mean platelet volume (MPV) were not affected by the administration of silk peptide. Especially, there were no differences in the number and rate (%) of immune cells such as lymphocytes as well as monocytes and granulocytes between vehicle and silk peptide-treated groups. Silk peptide neither affected the thymus and spleen weights, in addition to the cellularity in thymus, nor induced gross and microscopic lesions of thymus, spleen and lymph node. Taken together, 4-week administration of silk peptide up to 2,000 ㎎/㎏, the upper-limit dose in repeated-dose toxicity study, did not exhibit adverse effects on the immune systems, leading to no observed adverse effect level (NOAEL) higher than 2,000 ㎎/㎏. Without influence on the production, maturation and death process of immune cells at 20-fold dose of clinical dose (100 ㎎/㎏), silk peptide was evaluated to be a practically non-toxic material.
참고문헌 (Reference)
1 식품의약품안전청, "의약품등의 독성시험기준"
2 정윤화, "실크단백질 효소 가수분해물이 OLETF Rat의 혈당, 혈중 인슐린과 렙틴분비에 미치는 영향" 한국식품영양과학회 36 (36): 703-707, 2007
3 정윤화, "실크단백질 효소 가수분해물이 2형 당뇨 마우스의 혈당 및 혈청지질에 미치는 영향" 한국식품영양과학회 35 (35): 1343-1348, 2006
4 정윤화, "실크단백질 효소 가수분해물이 2형 당뇨 마우스 C57BL/KsJ db/db의 혈당에 미치는 영향" 한국식품영양과학회 35 (35): 1166-1171, 2006
5 한국보건공정서연구회, "건강기능식품의 기능성 시험 가이드" 2004
6 Gotoh, K., "Sulfate fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro" 64 : 1664-1670, 2000
7 Luo, J., "Study on foodization of fibroin and its functionality" 73-87, 1993
8 Lee, K.G., "Studies on industrial utilization of silk protein" 36 : 25-37, 2003
9 Park, K.J., "Stimulation of insulin secretion by silk fibroin hydrolysate in streptozotocin-induced diabetic rat and db/db mice" 333 : 21-28, 2002
10 Hwang, E., "Protein quality evaluation and effect of plasma contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet" 30 : 1004-1009, 2001
1 식품의약품안전청, "의약품등의 독성시험기준"
2 정윤화, "실크단백질 효소 가수분해물이 OLETF Rat의 혈당, 혈중 인슐린과 렙틴분비에 미치는 영향" 한국식품영양과학회 36 (36): 703-707, 2007
3 정윤화, "실크단백질 효소 가수분해물이 2형 당뇨 마우스의 혈당 및 혈청지질에 미치는 영향" 한국식품영양과학회 35 (35): 1343-1348, 2006
4 정윤화, "실크단백질 효소 가수분해물이 2형 당뇨 마우스 C57BL/KsJ db/db의 혈당에 미치는 영향" 한국식품영양과학회 35 (35): 1166-1171, 2006
5 한국보건공정서연구회, "건강기능식품의 기능성 시험 가이드" 2004
6 Gotoh, K., "Sulfate fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro" 64 : 1664-1670, 2000
7 Luo, J., "Study on foodization of fibroin and its functionality" 73-87, 1993
8 Lee, K.G., "Studies on industrial utilization of silk protein" 36 : 25-37, 2003
9 Park, K.J., "Stimulation of insulin secretion by silk fibroin hydrolysate in streptozotocin-induced diabetic rat and db/db mice" 333 : 21-28, 2002
10 Hwang, E., "Protein quality evaluation and effect of plasma contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet" 30 : 1004-1009, 2001
11 Lee, S.H., "Physiology functional characteristic of silk peptide" 35 : 57-62, 2002
12 Akai, H., "New physiological functions of silk material" 34 : 43-47, 1999
13 Tae Myoung Kim, "Effects of Red Ginseng Powder and Silk Peptide on Hypercholesterolemia and Atherosclerosis in Rabbits" 한국실험동물학회 24 (24): 67-75, 2008
14 Sugiyama, K., "Effect of sulfur containing amino acid and glycine on plasma cholesterol level in rats fed on a high cholesterol diet" 49 : 3455-3461, 1985
15 Nahm, J.H., "A study of pharmacological effect of silk fibroin" 37 : 145-157, 1995
Single and 28-day Repeated Dose Toxicity Studies of Coumarin in the Minipig
Prevalence and Causes of Wound of Rhesus Monkey in the Laboratory Nonhuman Primate Facility
Anti-inflammatory Activity of Methanolic Extract Isolated from Immature Fruit of Rhus succedanea
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2026 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2020-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2017-01-01 | 평가 | 등재학술지 유지 (계속평가) | |
2013-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2006-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2005-07-03 | 학술지명변경 | 한글명 : Korean Association For Laboratory Animal Science -> Laboratory Animal Research외국어명 : Korean Association For Laboratory Animal Science -> Laboratory Animal Research | |
2004-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.16 | 0.16 | 0.16 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.25 | 0.19 | 0.415 | 0.03 |