Preparation and Study of Dinuclear Zn(2) Complex for the Hydrolysis of Phosphate Esters

다국어 초록 (Multilingual Abstract)

It is well known that natural nucleases such as alkaline phosphatase, phospholipase C and P1 nuclease contain more than two metal ions in the active siteand there have been considerable research efforts in developing efficient catalysts carrying two or three metal ions for the hydrolysis of phosphate esters. In order to achieve a possible cooperativity among metal ions, it is crucial to design effective bi- and multinucleating ligands.
During the course of our study in synthesizing hydroxy alkyl-bridged binucleating ligands, we prepared a new Zn complex with ligand Ll. The reason for choosing 1,5,9-triazacyclododecane([12]aneN_(3)), L2, as a monomeric unit is that the mononuclear Zn-L2 complex is known to be thermally stable and an efficient catalyst in hydrolyzing phosphate esters. With this respect, very recently, a series of binuelcating ligands having tri- or tetraazacyclic ligands as a monomeric unit bridged by phenyl- and alkyl group, have been synthesized and chemical properties of a few of their Cu and Ni complexes have been reported. However their reactivity as a hydrolysis catalyst has never been tested. 1t would be worthwhile to know whether simple alkyl bridge could provide a cooperative interaction between metal ions. In this report, the reactivity of the Zn-L1 and the Zn-L2 complexes in hydrolyzing BDNPP, NPP was compared and the structural requirements of a binucleating ligand were investigated.

목차 (Table of Contents)

• Experimental Section
• Results and Discussion
• Acknowledgement
• References