酒精 禁斷과 마그네슘 注射 = Alcohol Withdrawal and Magnesium Injection

다국어 초록 (Multilingual Abstract)

The subjects were forty-two alcoholics, who were admitted in the Dept. of Neuropsyciatry of Maryknoll General Hospital from Sept.-1-1977 to Dec.-31-1984.
Since 1981, the authors of this abstract have treated the alcoholics with the intramuscular magnesium injections(50% MgSO₄with 2% Lidocaine 0.2cc) every 8hrs. for the first day during the acute withrawal days. We were interested in how much the magnesium injections were effective for the alcoholics; therefore we studied the good effects of the magnesium injection and the correlation of it's serum level.
The alcoholics were divided into two groups: 18 patients in the magnesium non-injected group, 24 patients in the magnesium injected group and the alcohol free group for the control.
The serum magnesium levels were checked before the injection in all cases and compared among the following classified group: alcoholics with Delirium Tremens(DT), alcoholics without Delirium Tremens(non-DT) and the alcohol free control group.
The serum magnesium mean levels were 2.045±0.366㎎/㎗(DT), 2.371±0.404㎎/㎗(non-DT) and 2.118±0.042㎎/㎗(control). These mean levels were all within normal limits. Especially, the level of DT was the lowest, which suggested that most of the alcoholics were admitted a few days after withdrawal. Meanwhile, until admission, the immediately dropped serum magnesium recovered spontaneously hour by hour but not sufficiently up to the level of the control group on admission.
There were no significant different features of symptoms on admission between the injected and non-injected group. But the injected group recovered more rapidly from hallucination(P<.02) and profound confusion, disorientation and delusion(P<.05). And also the severity of Delirium Tremens of the injected group was much less than the non-injected group(P<.02).
Through these experiences and the results, the authors stress the importance of magnesium injections for the treatment of alcoholics.