연에 의한 건강장해 및 생물학적 표식자 = Health Effects and Biological Markers of Lead

다국어 초록 (Multilingual Abstract)

Increasing evidence has demonstrated that adverse health effects of lead including neurobehavioral, reproductive, hematological, and growth problems occur at as low as acceptable blood lead level. The use of biomarkers is becoming important to detect biochemical and functional changes by lead at the cellular and molecular levels. Of the biomarkers of lead, blood lead is the most widely used as a measure of absorbed (internal) dose. The amount of plasma and urine after administration of a chelating agent reflects mobilizable pool of internal lead dose as bioavaliable lead burden. Lead in skeletal pools is an estimate of cumulative and past exposure. Lead toxicity is related to lead's affinity for a variety of enzyme systems such as heme synthesis pathway, sodium potassium ATPase, calcium transport and neurotransmitters. The range of health effects is diverse due to acquired and inherited susceptibility. This article briefly reviewed some of development and application of biomarkers of lead in relation to exposure, response, and susceptibility in occupational and public health research and practice. Particularly, biomarkers of lead were described in sequential progression between exposure and disease. This paper presented development of validated biomarkers that can contribute to occupational health efforts and applications that can bring to biological monitoring field.

목차 (Table of Contents)

• 1.머리말
• 2.본론
• (1) 납에 의한 인체장해
• (2) 생물학적 표식자의 개념
• (3) 납의 생물학적 표식자
• (4) 생물학적 표식자 활용의 고려할 점
• 3.맺음말