만성활동성간염에 대한 간추출제제의 임상효과 = The Clinical Trial of Liver Extract in Chronic Active Hepatitis만성활동성간염에 대한 간추출제제의 임상효과

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

The purified protein-free liver extracts have been used for past many years in the treatment of both acute and chronic liver diseases. To evaluate the therapeutic effect of liver extract, Adelavin, this clinical study was carried out in 25 HBsAg positive patients with histologically proven chronic active hepatitis. 4ml of Adelavin mixed with 5% dextrose in water 500 ml were infused intravenously daily for 4 weeks. The following results were obtained. 1) The subjective symptoms were improved after 4 weeks-administration by improvement rate 70% in fatigue, 60% in anorexia, 75% in nausea, 45% in indigestion, 67% in abdominal discomfort. 2) There were significant improvements in SGOT, SGPT, alkaline phosphatase, total protein after 2 weeks-administration than preadministration(p<0.01), in albumin after 4 weeks- administration (p<0.001), in prothrombin time after 3 weeks-administration (p<0. 05) 3) In serum protein electrophoresis, there was significant increase of albumin after 4 weeks- administration (p<0.001) and significant decrease of gamma globulin after 4 weeks-admini stration (p<0.001). 4) In radioimmunoassay, there was no change of Hepatitis B marker after
4 weeks-administration. 5) There was not any abnormality in complete blood count and urinalysis after 4weeks- administration, but the transient nausea was found in one patient, the mild acne in two patients, the skin rash with fever in one patient.