Recent Advances in 3D Bioprinted Tumor Microenvironment

다국어 초록 (Multilingual Abstract)

Tumors in vivo exist in a microenvironment, so-called tumor microenvironment (TME), which includes peripheral blood vessels, immune cells, fibroblasts, signalling molecules and extracellular matrix. In recent years, considerable efforts have been focused on developing bioprinting methods because 3D bioprinting can better recapitulate TMEs by accurately printing different types of TME cells in spatially localised regions. In this review, we first introduce TME and 3D bioprinting methods and later discuss bioprinted TMEs as tumor equivalents for understanding tumor biology as well as testing drug efficacy.

참고문헌 (Reference)

1 Han, S., "bioprinted vascularized tumour for drug testing" 21 : 2993-, 2020

2 Osidak, E. O., "Viscoll collagen solution as a novel bioink for direct 3D bioprinting" 30 : 31-, 2019

3 Wang, X., "Tumor-like lung cancer model based on 3D bioprinting" 8 : 501-, 2018

4 Katayama, Y., "Tumor neovascularization and developments in therapeutics" 11 : 316-, 2019

5 Schmidt, S. K., "Tumor cells develop defined cellular phenotypes after 3D-bioprinting in different bioinks" 8 : 1295-, 2019

6 Munaz, A., "Three-dimensional printing of biological matters" 1 : 1-17, 2016

7 Zhao, Y., "Three-dimensional printing of Hela cells for cervical tumor model in vitro" 6 : 035001-, 2014

8 Hermida, M. A., "Three dimensional in vitro models of cancer: Bioprinting multilineage glioblastoma models" 75 : 100658-, 2020

9 Whiteside, T.L., "The role of immune cells in the tumor microenvironment" 103-124, 2006

10 Muz, B., "The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy" 3 : 83-92, 2015

11 Xu, J., "TGF-β-induced epithelial to mesenchymal transition" 19 : 156-172, 2009

12 Yue, K., "Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels" 73 : 254-271, 2015

13 Sun, M., "Synthesis and properties of gelatin methacryloyl (GelMA) hydrogels and their recent applications in load-bearing tissue" 10 : 1290-, 2018

14 Xu, C., "Study of droplet formation process during drop-on-demand inkjetting of living cell-laden bioink" 30 : 9130-9138, 2014

15 Van Den Bulcke, A. I., "Structural and rheological properties of methacrylamide modified gelatin hydrogels" 1 : 31-38, 2000

16 Norotte, C., "Scaffold-free vascular tissue engineering using bioprinting" 30 : 5910-5917, 2009

17 Duchamp, M., "Sacrificial bioprinting of a mammary ductal carcinoma model" 14 : 1700703-, 2019

18 Gonzalez, H., "Roles of the immune system in cancer: from tumor initiation to metastatic progression" 32 : 1267-1284, 2018

19 Diao, J., "Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells" 11 : 025006-, 2019

20 Dzobo, K., "Recent trends in decellularized extracellular matrix bioinks for 3D printing: An updated review" 20 : 4628-, 2019

21 Ma, X., "Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture" 185 : 310-321, 2018

22 Berg, J., "Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus" 8 : 13877-, 2018

23 van Pel, D. M., "Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture" 12 : 723-730, 2018

24 Langer, E. M., "Modeling tumor phenotypes in vitro with three-dimensional bioprinting" 26 : 608-623, 2019

25 Jabłońska-Trypuć, A., "Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs" 31 : 177-183, 2016

26 Schiele, N. R., "Laser-based direct-write techniques for cell printing" 2 : 032001-, 2010

27 Kingsley, D. M., "Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies" 95 : 357-370, 2019

28 Hakobyan, D., "Laser-assisted 3D bioprinting of exocrine pancreas spheroid models for cancer initiation study" 12 : 035001-, 2020

29 Vinson, B. T., "Laser direct-write based fabrication of a spatially-defined, biomimetic construct as a potential model for breast cancer cell invasion into adipose tissue" 9 : 025013-, 2017

30 Wang, X., "Gelatin-based hydrogels for organ 3D bioprinting" 9 : 401-, 2017

31 Abbas, A. K., "Functional diversity of helper T lymphocytes" 383 : 787-793, 1996

32 Park, J. A., "Freeform micropatterning of living cells into cell culture medium using direct inkjet printing" 7 : 14610-, 2017

33 Braham, M. V. J., "Endosteal and perivascular subniches in a 3D bone marrow model for multiple myeloma" 24 : 300-312, 2018

34 Jiang, T., "Directing the self-assembly of tumour spheroids by bioprinting cellular heterogeneous models within alginate/gelatin hydrogels" 7 : 4575-, 2017

35 Masaeli, E., "Direct-write bioprinting approach to construct multilayer cellular tissues" 7 : 478-, 2020

36 Gu, Z., "Development of 3D bioprinting: from printing methods to biomedical applications" 2019

37 Wang, X., "Coaxial extrusion bioprinted shell-core hydrogel microfibers mimic glioma microenvironment and enhance the drug resistance of cancer cells" 171 : 291-299, 2018

38 Dai, X., "Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers" 7 : 1457-, 2017

39 Mondal, A., "Characterization and printability of Sodium alginate-Gelatin hydrogel for bioprinting NSCLC co-culture" 9 : 19914-, 2019

40 Liu, T., "Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy" 12 : 86-, 2019

41 Hu, W., "Cancer immunotherapy based on natural killer cells:cur-rent progress and new opportunities" 10 : 1205-, 2019

42 Cirri, P., "Cancer associated fibroblasts:the dark side of the coin" 1 : 482-497, 2011

43 Harty, J. T., "CD8+T cell effector mechanisms in resistance to infection" 18 : 275-308, 2000

44 Zhang, Y. S., "Bioprinting the cancer microenvironment" 2 : 1710-1721, 2016

45 Wang, X., "Bioprinting of glioma stem cells improves their endotheliogenic potential" 171 : 629-637, 2018

46 Swaminathan, S., "Bioprinting of 3D breast epithelial spheroids for human cancer models" 11 : 025003-, 2019

47 Knowlton, S., "Bioprinting for cancer research" 33 : 504-513, 2015

48 Lee, C., "Bioprinting a novel glioblastoma tumor model using a fibrin-based bioink for drug screening" 12 : 78-84, 2019

49 Guermonprez, P., "Antigen presentation and T cell stimulation by dendritic cells" 20 : 621-667, 2002

50 Xu, M., "An cell-assembly derived physiological 3D model of the metabolic syndrome, based on adipose-derived stromal cells and a gelatin/alginate/fibrinogen matrix" 31 : 3868-3877, 2010

51 Hou, S., "Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening" 23 : 574-584, 2018

52 Peela, N., "Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis" 133 : 176-207, 2017

53 Xu, F., "A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform" 6 : 204-212, 2011

54 Yi, H. -G., "A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy" 3 : 509-519, 2019

55 Zhou, X., "A 3D bioprinting liver tumor model for drug screening" 5 : 196-213, 2016

56 Reid, J. A., "A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids" 9 : 7466-, 2019

57 Mirani, B., "A 3D bioprinted hydrogel mesh loaded with all-trans retinoic acid for treatment of glioblastoma" 854 : 201-212, 2019

58 Heinrich, M. A., "3D-bioprinted minibrain:A glioblastoma model to study cellular interactions and therapeutics" 31 : 1806590-, 2019

59 Murphy, S. V., "3D bioprinting of tissues and organs" 32 : 773-785, 2014

60 Zhang, Z., "3D bioprinting of soft materials-based regenerative vascular structures and tissues" 123 : 279-291, 2017

61 Wang, Y., "3D bioprinting of breast cancer models for drug resistance study" 4 : 4401-4411, 2018

62 Zhou, X., "3D bioprinting a cell-laden bone matrix for breast cancer metastasis study" 8 : 30017-30026, 2016

63 Mollica, P. A., "3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels" 95 : 201-213, 2019

64 Meng, F., "3D bioprinted in vitro metastatic models via reconstruction of tumor microenvironments" 31 : 1806899-, 2019

65 Dai, X., "3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility" 8 : 045005-, 2016

66 Wang, X., "3D bioprinted glioma cell-laden scaffolds enriching glioma stem cells via epithelial–mesenchymal transition" 107 : 383-391, 2019

67 Xie, M., "3D biofabrication of microfiber-laden minispheroids:a facile 3D cell co-culturing system" 8 : 109-117, 2020