Relationship between the Lamina Cribrosa, Outer Retina, and Choroidal Thickness as Assessed Using Spectral Domain Optical Coherence Tomography

다국어 초록 (Multilingual Abstract)

Purpose: To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), laminacribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectraldomain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI).
Methods: In total, 255 participants were included (87 healthy subjects, 87 glaucoma suspects (GS), and 81glaucoma cases). The pORT, defined as the thickness between the posterior outer plexiform layer and theretinal pigment epithelium (RPE) interface, and the pCT, between the outer margin of the RPE and the choroidal-scleral interface, were manually measured using EDI scanning of the circumpapillary retinal nerve fiberlayer (RNFL). LCT was determined by EDI scanning of the optic nerve head (ONH). Baseline characteristics,including axial length (AXL) and the SD-OCT measurements of the participants, were compared among thethree groups. The correlation between putative factors and pCT was determined using univariate and multivariatelinear regression analyses.
Results: In all three groups, both pORT and pCT were thinnest in the inferior area among the four quadrants. Inthe healthy group, the mean peripapillary RNFL, pORT, and LCT were significantly greater in comparison withthose of the GS and glaucoma groups (p < 0.001, p < 0.038, and p < 0.001, respectively). The pCT demonstratedno significant differences among the three groups (p = 0.083). Only age and AXL were associatedwith pCT by multivariate analysis.
Conclusions: The pCT is substantially thinner in the inferior area of the ONH. In addition, the pCT demonstratesthe strongest correlation with age and AXL, but was not associated with glaucoma or LCT.

참고문헌 (Reference)

1 Lee EJ, "Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography" 152 : 87-95, 2011

2 Sung KR, "Twenty-four hour ocular perfusion pressure fluctuation and risk of normal-tension glaucoma progression" 50 : 5266-5274, 2009

3 Iwase A, "The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study" 111 : 1641-1648, 2004

4 Sung KR, "Retinal nerve fiber layer normative classification by optical coherence tomography for prediction of future visual field loss" 52 : 2634-2639, 2011

5 Ikuno Y, "Reproducibility of retinal and choroidal thickness measurements in enhanced depth imaging and high-penetration optical coherence tomography" 52 : 5536-5540, 2011

6 Branchini L, "Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems" 119 : 119-123, 2012

7 Cho JW, "Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography" 51 : 6401-6407, 2010

8 Quigley HA, "Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage" 99 : 137-143, 1981

9 Sung KR, "Progression detection capability of macular thickness in advanced glaucomatous eyes" 119 : 308-313, 2012

10 Kim CS, "Prevalence of primary open-angle glaucoma in central South Korea the Namil study" 118 : 1024-1030, 2011

11 Ehrlich JR, "Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography" 92 : 189-194, 2011

12 Sugiyama K, "Optic nerve and peripapillary choroidal microvasculature of the rat eye" 40 : 3084-3090, 1999

13 Jonas JB, "Morphometry of the human lamina cribrosa surface" 32 : 401-405, 1991

14 Na JH, "Macular and retinal nerve fiber layer thickness: which is more helpful in the diagnosis of glaucoma?" 52 : 8094-8101, 2011

15 Seong M, "Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma" 51 : 1446-1452, 2010

16 Mwanza JC, "Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography" 52 : 3430-3435, 2011

17 Usui S, "Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma" 153 : 10-16, 2012

18 Kim S, "Evaluation of lamina cribrosa in pseudoexfoliation syndrome using spectral-domain optical coherence tomography enhanced depth imaging" 120 : 1798-1803, 2013

19 Fujiwara T, "Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes" 148 : 445-450, 2009

20 Park SC, "Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma" 119 : 3-9, 2012

21 Park HY, "Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma" 119 : 10-20, 2012

22 Chakraborty R, "Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics" 52 : 5121-5129, 2011

23 Tan CS, "Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography" 53 : 261-266, 2012

24 Toyokawa N, "Difference in morning and evening choroidal thickness in Japanese subjects with no chorioretinal disease" 43 : 109-114, 2012

25 Na JH, "Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography" 53 : 3817-3826, 2012

26 Usui S, "Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects" 53 : 2300-2307, 2012

27 Cioffi GA, "Chronic ischemia induces regional axonal damage in experimental primate optic neuropathy" 122 : 1517-1525, 2004

28 Maul EA, "Choroidal thickness measured by spectral domain optical coherence tomography:factors affecting thickness in glaucoma patients" 118 : 1571-1579, 2011

29 Mwanza JC, "Choroidal thickness in unilateral advanced glaucoma" 53 : 6695-6701, 2012

30 Duijm HF, "Choroidal haemodynamics in glaucoma" 81 : 735-742, 1997

31 Sung KR, "Characteristics of visual field progression in medically treated normal-tension glaucoma patients with unstable ocular perfusion pressure" 52 : 737-743, 2011

32 Um TW, "Asymmetry in hemifield macular thickness as an early indicator of glaucomatous change" 53 : 1139-1144, 2012

33 Radius RL, "Anatomy of the lamina cribrosa in human eyes" 99 : 2159-2162, 1981

34 Margolis R, "A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes" 147 : 811-815, 2009