This study investigated the effects of hydroxylase cyptochrome P450 inducers on the efficiency of the biotransformation of dehydroepiandrosterone (DHEA) to 3β, 7α, 15α-trihydroxy-5-androsten-17-one (7α,15α-diOHDHEA)by Colletotrichum lini ST-1. Sp...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A103816107
Hui Li (Jiangnan University) ; Zhenzhen Fu (Jiangnan University) ; Heng Li (Jiangnan University) ; Wenfang Dou (Jiangnan University) ; Jinsong Shi (Jiangnan University) ; Zhenghong Xu (Jiangnan University)
2013
English
KCI등재,SCIE,SCOPUS
학술저널
486-490(5쪽)
1
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
This study investigated the effects of hydroxylase cyptochrome P450 inducers on the efficiency of the biotransformation of dehydroepiandrosterone (DHEA) to 3β, 7α, 15α-trihydroxy-5-androsten-17-one (7α,15α-diOHDHEA)by Colletotrichum lini ST-1. Sp...
This study investigated the effects of hydroxylase cyptochrome P450 inducers on the efficiency of the biotransformation of dehydroepiandrosterone (DHEA) to 3β, 7α, 15α-trihydroxy-5-androsten-17-one (7α,15α-diOHDHEA)by Colletotrichum lini ST-1. Special attention was given to the substrate DHEA being the best inducer and the fact that it could improve the yield of 7α, 15α-diOHDHEA.
Based on the effects of the DHEA pre-induction phases and additional concentrations on 7α, 15α-diOHDHEA production, a substrate pre-induction process was established as follows: 2 g/L DHEA was added for the first time after 12 h of inoculation, followed by the second addition of 6 g/L DHEA after 12 h later. The results showed that this substrate pre-induction process improved the content of cytochrome P450 and that the 7α, 15α-diOH-DHEA yield reached 90.1%, which was 26.9%higher than that obtained in the original process.
참고문헌 (Reference)
1 Mutafov, S., "The inducibility of 9α-steroid hydroxylating activity in resting Rhodococcus sp. cells" 32 : 585-589, 1997
2 Romano, A., "Steroid hydroxylations with Botryodiplodia malorum and Colletotrichum lini" 71 : 429-434, 2006
3 Marques, M. P. C., "Steroid bioconversion: Towards green processes" 88 : 12-20, 2010
4 Lobastova, T. G., "Screening of mycelial fungi for 7α- and 7β-hydroxylase activity towards dehydroepiandrosterone" 25 : 434-442, 2007
5 Shen, Y. J., "Progesterone hydroxylation with Colletotrichum lini AS3. 4486" 343 : 1070-1073, 2012
6 Ahmed, E. M., "Production of 11α-hydroxyprogesterone using Aspergillus terreus immobilized on polytetrafluoroethylene" 38 : 224-229, 2007
7 Smith, K. E., "Microbial transformations of steroids-VIII. Transformation of progesterone by whole cells and microsomes of Aspergillus fumigatus" 49 : 93-100, 1994
8 Donova, M. V., "Microbial steroid transformations: Current state and prospects" 94 : 1423-1447, 2012
9 Carballeira, J. D., "Microbial cells as catalysts for stereo selective redox reactions" 27 : 686-714, 2009
10 Andryushina, V. A., "Hydroxylation of steroids by Curvularia lunata mycelium in the presence of methyl-β-cyclodextrine" 47 : 42-48, 2011
1 Mutafov, S., "The inducibility of 9α-steroid hydroxylating activity in resting Rhodococcus sp. cells" 32 : 585-589, 1997
2 Romano, A., "Steroid hydroxylations with Botryodiplodia malorum and Colletotrichum lini" 71 : 429-434, 2006
3 Marques, M. P. C., "Steroid bioconversion: Towards green processes" 88 : 12-20, 2010
4 Lobastova, T. G., "Screening of mycelial fungi for 7α- and 7β-hydroxylase activity towards dehydroepiandrosterone" 25 : 434-442, 2007
5 Shen, Y. J., "Progesterone hydroxylation with Colletotrichum lini AS3. 4486" 343 : 1070-1073, 2012
6 Ahmed, E. M., "Production of 11α-hydroxyprogesterone using Aspergillus terreus immobilized on polytetrafluoroethylene" 38 : 224-229, 2007
7 Smith, K. E., "Microbial transformations of steroids-VIII. Transformation of progesterone by whole cells and microsomes of Aspergillus fumigatus" 49 : 93-100, 1994
8 Donova, M. V., "Microbial steroid transformations: Current state and prospects" 94 : 1423-1447, 2012
9 Carballeira, J. D., "Microbial cells as catalysts for stereo selective redox reactions" 27 : 686-714, 2009
10 Andryushina, V. A., "Hydroxylation of steroids by Curvularia lunata mycelium in the presence of methyl-β-cyclodextrine" 47 : 42-48, 2011
11 Kolek, T., "Hydroxylation of DHEA, androstenediol and epiandrosterone by Mortierella isabellina AM212. Evidence indicating that both constitutive and inducible hydroxylases catalyze 7α- as well as 7β-hydroxylations of 5-ene substrates" 9 : 5414-5422, 2011
12 Mahato, S. B., "Garai(1997)Advances in microbial steroid biotransformation" 62 : 332-345, 1997
13 Lu, W. Y., "Effect of two-steps substrate addition on steroids 11α- hydroxylation by Curvularia lunata CL-114" 32 : 233-238, 2006
14 Bernhardt, R., "Cytochromes P450 as versatile biocatalysts" 24 : 128-145, 2006
15 Pollard, D. J., "Biocatalysis for pharmaceutical intermediates: The future is now" 25 : 66-73, 2006
16 Andriushina, V. G., "7α-Hydroxylation of steroid 5α-olefins by mold fungi" 46 : 69-74, 2010
17 Chen, K. C., "11β-Hydroxylation of coxtexolone by Curvularia lunata" 12 : 305-308, 1990
Degradation of Formaldehyde in Packed-bed Bioreactor by Kissirisimmobilized Ralstonia eutropha
Growth and Triterpenic Acid Accumulation of Cyclocarya paliurus Cell Suspension Cultures
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.14 | 0.13 | 0.75 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.57 | 0.46 | 0.239 | 0.02 |