TDP병리가 확인된 근위축측삭경화증 부검 증례 = An Autopsy Confirmed Case of Amyotrophic Lateral Sclerosis with TDP Pathology

다국어 초록 (Multilingual Abstract)

The phosphorylated 43-kDa transactive response DNA-binding protein (TDP-43) was identified as a major disease protein in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We present a case with progressive muscle weakness who was diagnosed with sporadic ALS. On postmortem examination, TDP-43 immunoreactive neuronal cytoplasmic inclusions were noted in motor cortex, hippocampus and anterior horns of spinal cord, which was compatible with ALS-TDP, stage 4. This is the first documented autopsy-confirmed ALS case with ALS-TDP pathology in Korea.

참고문헌 (Reference)

1 김은주 ; 오은혜 ; 김기태 ; 정유리 ; 이정희 ; 이재혁 ; 이영민 ; 김성장 ; 신진홍 ; 이명준 ; 안재우 ; 성석 ; 정대수 ; William W. Seeley ; 허기영 ; 최경운 ; 신명준, "전두측두엽치매-운동신경세포질환의 부검증례" 대한신경과학회 33 (33): 201-205, 2015

2 하승현 ; 백원기 ; 김현영 ; 노민영 ; 황세진 ; 김승현, "부검에서 신경염증 변화를 확인한 근위축측삭경화증 환자" 대한신경과학회 30 (30): 128-131, 2012

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