A Study on Cerebral Hemodynamic Analysis of Moyamoya Disease by Using Perfusion MRI

다국어 초록 (Multilingual Abstract)

This study examined the clinical applications of perfusion magnetic resonance imaging (MRI) inpatients with moyamoya disease (MMD). Twenty-two patients with moyamoya disease (9 men and13 women) with a mean age of 9.3 years (range: 4 - 22 years) were enrolled in this study. PerfusionMRI was performed by scanning the patients7.5 cm upward from the base of the cerebellum beforetheir being process for post-treatment. The scan led to the acquisition of the following four mapimages: the cerebral blood volume (CBV), the cerebral blood flow (CBF), the mean transit time(MTT) for the contrast medium, and the time to peak (TTP) for the contrast medium. The lesionswere assessed using the CBV, the CBF, the MTT and the TTP maps of perfusion MRI; the MTTand the TTP were measured in the lesion areas, as well as in the normal and the symmetric areas.
Perfusion defects were recognizable in all four perfusion MRI maps, and the MTT and the TTPshowed a conspicuous delay in the parts where perfusion defects were recognized. The MTT and theTTP images of perfusion MRI reflected a significant correlation between the degrees of stenosis andocclusion in the posterior cerebral artery (PCA), as well as the development of collateral vessels.
The four perfusion MRI maps could be used to predict the degrees of stenosis and occlusion inthe posterior circulation, as well as the development of the collateral vessels, which enabled ahemodynamic evaluation of the parts with perfusion defects. Overall, perfusion MRI is useful forthe diagnosis and the treatment of moyamoya disease and can be applied to clinical practice.

참고문헌 (Reference)

1 H. K. Yoon., 223 : 384-, 2002

2 T. J. Yun., 252 : 216-, 2009

3 Y. Fushimi., 239 : 232-, 2006

4 J. Suzuki., 20 : 288-, 1969

5 J. Suzuki., 22 : 223-, 1971

6 S. K. Kim., 38 : 68-, 2003

7 M. Hirata., 20 : 327-, 1998

8 R. R. Edelman., 176 : 211-, 1990

9 M. Maeda., 189 : 227-, 1993

10 K. A. Rempp., 193 : 637-, 1994

11 J. A. Detre., 23 : 37-, 1992

12 R. Grueneich., 29 : 83-, 2004

13 R. Luypaert., 38 : 19-, 2001

14 B. R. Rosen., 22 : 293-, 1991

15 L. M. Parkes., 48 : 27-, 2002

16 T. N. Neumann-Haefelin., 30 : 1591-, 1999

17 M. Wintermark., 11 : 1220-, 2001

18 T. E. Mayer., 2 : 1441-, 2000

19 M. J. van Osch., 49 : 1067-, 2003

20 M. J. van Osch., 22 : 704-, 2005

21 F. Calamante., 52 : 789-, 2004

22 P. S. Tofts., 17 : 357-, 1991

23 장건호, "관류 자기공명영상의 원리 및 기술" 대한자기공명의과학회 15 (15): 91-101, 2011