말초 opioid 수용체에 의한 저작근 통증의 조절 효과 = Effect of Peripheral Opioid Receptor on Masticatory Muscle Pain Control

국문 초록 (Abstract)

이 연구는 저작근 통증 환자에게 Morphine을 주사하였을 때의 조절 효과를 확인하기 위해서 시행되었으며, 경희대학교 치과대학병원 구강내과에 내원한 환자 중 RDC/TMD로 근막통증으로 진단된 환자들이 지원하였다. 실험군은 총 네 군으로 구성되었으며 saline 주사군, lidocaine 주사군, morphine 1.5mg 주사군, morphine 3.0 mg 주사군에 각각 10명씩 배정하였다. 통증부위에 주사 전, 주사 후 1시간, 24시간, 48시간에 각각 주관적인 통증 평가인 시각유추척도검사, 맥길통증설문지검사 그리고 통증부위표시검사와 객관적인 통증 평가인 압력통증역치검사와 압력통증한계검사를 실시하였다. 검사 후 평가된 자료를 통계 처리하여 다음과 같은 결과를 얻었다. 1. 주관적인 통증평가에서 morphine 3 mg 군은 48시간 후 통계학적으로 유의성 있는 효과가 있었다.(VAS: p<0.01, MGQ: p<0.001, PD: p<0.05) 2. 객관적인 통증평가에서 morphine 1.5 mg 군은 1시간 후 통계학적으로 유의성 있는 효과가 있었다.(PPT: p<0.01, PPTol: p<0.05) 3. 맥길통증설문지에서 lidocaine 군, morphine 1.5 mg 군 그리고 morphine 3 mg 군은 모두 처치 후 1시간부터 효과가 있었으나 상대적으로 morphine 3 mg 군에서 통계학적으로 유의성 있게 더 큰 효과가 있었다.(1h: p<0.01, 24h: p<0.01, 48h: p<0.001) 이상의 연구 결과로 저작근에 통증이 있는 환자에게 morphine 주사 시 주관적인 평가에서 48시간 후 통증 조절 효과가 있었고, morphine 3 mg이 더 효과가 있었으며, 향후 시간 연장에 따른 지속적인 추가 연구가 필요 할 것으로 생각된다.

다국어 초록 (Multilingual Abstract)

This study was designed to evaluate the pain control effect by morphine injection to masticatory muscle pain patients. Patients with masticatory muscle pain visited the Department of Oral Medicine, Kyung Hee University Dental Hospital were recruited to this study and diagnosed by RDC/TMD. Experimental group were divided into four group; saline injection group (n=10), lidocaine injection group (n=10), morphine 1.5 mg injection group (n=10) and morphine 3 mg injection group (n=10). Evaluation list was the subjective pain evaluation(visual analogue scale, Mc Gill pain questionnaire, pain drawing) and the objective pain evaluation(pressure pain threshold, pressure pain tolerance) and evaluation time was injection before, after 1 hour, 24 hour, 48 hour and then it was analyzed statistically. The results were as follows : 1. The subjective pain evaluation were significantly different statistically in morphine 3 mg group after 48 hour. (VAS: p<0.01, MGQ: p<0.001, PD: p<0.05) 2. The objective pain evaluation were significantly different statistically in morphine 1.5 mg group after 1 hour. (PPT: p<0.01, PPTol: p<0.05) 3. The morphine 3 mg group were more significantly different than lidocaine group and morphine 1.5 mg group statistically in the McGill pain questionnaire evaluation. (1h: p<0.01, 24h: p<0.01, 48h: p<0.001) Therefore, it was revealed that the morphine 3 mg injection was effective to pain control for masticatory muscle pain patients within 48 hours and more effect than lidocaine injection.

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