저선량 방사선이 인체에 미치는 영향 = The health effects of low-dose radiation exposure

다국어 초록 (Multilingual Abstract)

Low dose radiation has been defined as doses in the range under 100 mSv of low linear energy transfer (low-LET) radiation. There are two sources of ionizing radiation: natural and artificial radiation. Medical radiation exposure is the most common artificial radiation exposure.
The frequency and volume of medical radiation exposure has markedly increased because of recent developments in medical technology. Radiation protection is now a concern due to the increasing use of computed tomography (CT) scans and diagnostic X-rays. This article introduced several models and hypotheses regarding the possible carcinogenic risks associated with low-LET radiation. Although opinions vary on the health effects of low level radiation exposure, current studies of medical radiation rely on exposure information collected prospectively, including cohort studies such as atomic bomb survivor studies. Although there are differences in perspective, the majority of studies have supported ‘linear-no-threshold model without threshold’ between low-LET radiation and the incidence of cancer risk. There is a need for further studies on medical radiation exposure including CT and positron emission tomography in order to understand the health effects of low-LET radiation, including the cancer incidence.

참고문헌 (Reference)

1 Sodickson A, "cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults" 251 : 175-184, 2009

2 Tubiana M, "The linear no-threshold relationship is inconsistent with radiation biologic and experimental data" 251 : 13-22, 2009

3 Greenpiece International, "The Chernobyl catastrophe: consequences on human health" Greenpiece 2006

4 "The AAPM statement on radiation dose from computed tomography, in response to the Brenner and Hall NEJM article published Nov 29, 2007 [Internet]. College Park (MD): American Association of Physicists in Medicine"

5 Preston DL, "Solid cancer incidence in atomic bomb survivors: 1958-1998" 168 : 1-64, 2007

6 National Radiological Protection Board, "Risk of radiation-induced cancer at low doses and low dose rates for radiation protection purposes" National Radiological Protection Board 1995

7 Doll R, "Risk of childhood cancer from fetal irradiation" 70 : 130-139, 1997

8 Berrington de Gonzalez A, "Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries" 363 : 345-351, 2004

9 United Nations Scientific Committee on the Effects of Atomic Radiation, "Report of the United Nations scientific on the effects of atomic radiation" United Nations 2010

10 Radiation risk in perspective: position statement of the Health Physics Society, "McLean (VA): Health Physics Society"

11 Valentin J, "Low-dose extrapolation of radiation-related cancer risk" 35 : 1-140, 2005

12 Knudsen LB, "Legally induced abortions in Denmark after Chernobyl" 45 : 229-231, 1991

13 United Nations Scientific Committee on the Effects of Atomic Radiation, "Ionizing radiation: sources and biologic effects" United Nations 1982

14 Czeizel AE, "Incidence of legal abortions and congenital abnormalities in Hungary" 45 : 249-254, 1991

15 Odlind V, "Incidence of legal abortion in Sweden after the Chernobyl accident" 45 : 225-228, 1991

16 International Agency for Research on Cancer, "IARC monographs on the evaluation of carcinogenic risks to humans. Ionizing radiation: part 1. X- and gamma-radiation and neutrons" International Agency for Research on Cancer 2000

17 Bennett B, "Health effects of the Chernobyl accident and special health care programmes" World Health Organization 2006

18 "Health effects of low-level radiation: position statement" American Nuclear Society

19 National Council on Radiation Protection and Measurements, "Evaluation of the linear-nonthreshold dose-response model for ionizing radiation" National Council on Radiation Protection and Measurements 2001

20 Einstein AJ, "Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography" 298 : 317-323, 2007

21 Brenner D, "Estimated risks of radiation-induced fatal cancer from pediatric CT" 176 : 289-296, 2001

22 United Nations Scientific Committee on the Effects of Atomic Radiation, "Effect of ionizing radiation: UNSCEAR 2006 report to the general assembly with scientific annexes" United Nations 2006

23 Tubiana M, "Dose-effect relationship and estimation of the carcinogenic effects of low doses of ionizing radiation: the joint report of the Academie des Sciences (Paris) and of the Academie Nationale de Medecine" 63 : 317-319, 2005

24 Brenner DJ, "Computed tomography: an increasing source of radiation exposure" 357 : 2277-2284, 2007

25 National Research Council, "Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. Health risks from exposure to low levels of ionizing radiation: BEIR VII phase 2" National Academies Press 2006

26 Brenner DJ, "Cancer risks attributable to low doses of ionizing radiation: assessing what we really know" 100 : 13761-13766, 2003

27 Little MP, "Berrington de Gonzalez A. Risks associated with low doses and low dose rates of ionizing radiation: why linearity may be (almost) the best we can do" 251 : 6-12, 2009