楡白皮가 抗炎作用에 미치는 影響 = Experimental study on the Anti-inflammatory and wound healing effect of Ulmus parvifolia

다국어 초록 (Multilingual Abstract)

Ulmus parvifolia(UP) is important prescriptions that have been used in oriental medicine for stomatitis and wound healing. The study was done to evaluate the inhibitory effects of cytotoxicity, formation of superoxide on the macrophage and neutrophil, prostaglandins(PGE2), interleukins(IL-1,β), collagenase activity and synthesis of collagen and DNA.
The results were obtained as follows:
1. UP was not showed the proliferation difference of human fibroblast and monocyte in all concentrations to be experimented and in result, it was concluded that they have no cytotoxicity.
2. UP inhibited the formation of superoxide to 22% at 0.01%, 52% at 0.001% in the mouse monocyte.
3. UP inhibited the formation of superoxide to 6% at the concentration of 0,001% as compared with control in the human monocyte.
4. UP was not showed the proliferation difference of human neutrophil in all concentrations to be experimented and in result, it was concluded that they inhibited the formation of superoxide.
5. UP was not showed the proliferation difference of human monocyte in all concentrations to be experimented and in result, it was concluded that they inhibited the formation of prostaglandins(PGE_2) in the human monocyte stimulated with E. coli.
6. UP was showed the all concentration of inhibiting the production of interleukins(IL-1,β) to slight in the human monocyte stimulated with E. coli.
7. UP influence on collagen synthesis and total protein in fibroblasts to at the slight of 0.05%, specially to excellent to 0.2%.
8. UP inhibited the collagenase activity to 20% at 0.1%, 31% at 0.2%, 45% at 0.5%, 24% at 0.01% respectively.