Albumin and cholinesterase were synthesized in the hepatic cells and circulate through blood stream. In the renal disease, determination of serum albumin alone is not a proper method for the information on the hepatic ability of protein synthesis, sin...
Albumin and cholinesterase were synthesized in the hepatic cells and circulate through blood stream. In the renal disease, determination of serum albumin alone is not a proper method for the information on the hepatic ability of protein synthesis, since a lot of albumin can be excreted into the urine. With this concept, this study was carried out to evaluate the significance of dete- rmination of cholinesterase in nephrotic syndrome.
The cholinesterase activity in the plasma in 81 normal persons was 0,90±0.09 dpH/hr.
In 13 nephrotic syndrome, chelinesterase activity in the plasma(2.89±. 92 dpH/hr) was significant increase than control values. The control values of serum albumin in normal persons was 4 .3±0.36 mg/100 ml, while the that in nephrotic syndrome (2. 42 ± 1. 36 mg/100 ml) was significant decrease.
The cholinesterase activity taken during acute pyelonephritis was slightly decrease, although not significant. However there was significant decrease in plasma albumin.
The cholinesterase activity in tlood taken from patient in cirrhosis of the liver was lower than the normal, although not significant. Howe- ver the plasma albumin was significant lower than that of the normal.
By the data obtained, it is suggested that dete- rmination of cholinesterase activity in blood will be a simple and accurate method for information on the hepatic ability of albumin synthesis in the nephrotic syndrome.