거골 골연골병변에 대한 수술적 치료: 골수 흡인물 농축액 및 기질 유래 연골 형성 = Operative Treatment for Osteochondral Lesions of the Talus: Bone Marrow Aspirate Concentrate and Matrix-induced Chondrogenesis

다국어 초록 (Multilingual Abstract)

Bone marrow aspirate concentrate and matrix-induced chondrogenesis (BMIC) is an interesting treatment option for osteochondral lesions of the talus with promising short- to mid-term results. The various terminologies used to describe this surgical method need to be addressed. These include bone marrow-derived cell transplantation, matrix-induced bone marrow aspirate concentrate, and matrixassociated stem cell transplantation. BMIC is a one-stage, minimally invasive surgery performed arthroscopically or using a mini-open arthrotomy approach without a malleolar osteotomy in most cases. The lesion is replaced with hyaline-like cartilage, and treatmentrelated complications are rare. BMIC is a safe and effective treatment option and should be considered in large lesions or lesions with a prior treatment history.

참고문헌 (Reference)

1 Wang D, "Vascular compromising effect of drilling for osteochondral lesions of the talus : a three-dimensional micro-computed tomography study" 35 : 2930-2937, 2019

2 Sadlik B, "Surgical repair of osteochondral lesions of the talus using biologic inlay osteochondral reconstruction: clinical outcomes after treatment using a medial malleolar osteotomy approach compared to an arthroscopically-assisted approach" 25 : 449-456, 2019

3 Vannini F, "Return to sports after bone marrow-derived cell transplantation for osteochondral lesions of the talus" 8 : 80-87, 2017

4 DʼAmbrosi R, "Return to sport after arthroscopic autologous matrix-induced chondrogenesis for patients with osteochondral lesion of the talus" 29 : 470-475, 2019

5 Desando G, "Repair potential of matrix-induced bone marrow aspirate concentrate and matrix-induced autologous chondrocyte implantation for talar osteochondral repair : patterns of some catabolic, inflammatory, and pain mediators" 8 : 50-60, 2017

6 Buda R, "Regenerative treatment in osteochondral lesions of the talus : autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation" 39 : 893-900, 2015

7 Galla M, "Open reconstruction with autologous spongiosa grafts and matrix-induced chondrogenesis for osteochondral lesions of the talus can be performed without medial malleolar osteotomy" 27 : 2789-2795, 2019

8 Giannini S, "One-step repair in talar osteochondral lesions : 4-year clinical results and t2-mapping capability in outcome prediction" 41 : 511-518, 2013

9 Giannini S, "One-step bone marrow-derived cell transplantation in talar osteochondral lesions" 467 : 3307-3320, 2009

10 Yontar NS, "One step treatment of talus osteochondral lesions with microfracture and cell free hyaluronic acid based scaffold combination" 53 : 372-375, 2019

11 Richter M, "Matrix-associated stem cell transplantation(MAST)in chondral lesions at the ankle as part of a complex surgical approach-5-year-follow-up in 100 patients" 25 : 264-271, 2019

12 Richter M, "Matrix-associated stem cell transplantation(MAST)in chondral defects of the 1st metatarsophalangeal joint is safe and effective-2-year-follow-up in 20 patients" 23 : 195-200, 2017

13 Richter M, "Matrix-associated stem cell transplantation(MAST)in chondral defects of foot and ankle is effective" 19 : 84-90, 2013

14 Murphy EP, "Matrix-associated stem cell transplantation is successful in treating talar osteochondral lesions" 27 : 2737-2743, 2019

15 Chen H, "Depth of subchondral perforation influences the outcome of bone marrow stimulation cartilage repair" 29 : 1178-1184, 2011

16 Eren TK, "Comparison of arthroscopic microfracture and cell-free scaffold implantation techniques in the treatment of talar osteochondral lesions" 30 : 97-105, 2019

17 Sadlik B, "Biological reconstruction of large osteochondral lesions of the talar dome with a modified "sandwich" technique-Midterm results" 23 : 290-295, 2017

18 Benthien JP, "Autologous matrix-induced chondrogenesis(AMIC) : combining microfracturing and a collagen I/III matrix for articular cartilage resurfacing" 1 : 65-68, 2010

19 Weigelt L, "Autologous matrix-induced chondrogenesis for osteochondral lesions of the talus : a clinical and radiological 2-to 8-year follow-up study" 47 : 1679-1686, 2019

20 Hannon CP, "Arthroscopic bone marrow stimulation and concentrated bone marrow aspirate for osteochondral lesions of the talus : a case-control study of functional and magnetic resonance observation of cartilage repair tissue outcomes" 32 : 339-347, 2016

21 Usuelli FG, "Allarthroscopic AMIC®(AT-AMIC®)technique with autologous bone graft for talar osteochondral defects : clinical and radiological results" 26 : 875-881, 2018

22 Volz M, "A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years" 41 : 797-804, 2017

23 Murphy EP, "A prospective evaluation of bone marrow aspirate concentrate and microfracture in the treatment of osteochondral lesions of the talus" 25 : 441-448, 2019

24 Buda R, ""One-step" bone marrow-derived cells transplantation and joint debridement for osteochondral lesions of the talus in ankle osteoarthritis:clinical and radiological outcomes at 36 months" 136 : 107-116, 2016