임상연구 : 중이수술 후 오심과 구토 예방을 위해 투여한 Midazolam의 효과 = Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery

다국어 초록 (Multilingual Abstract)

Background: Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery. Methods: In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation. Results: The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P ＜ 0.05). There were no significant differences between groups in adverse events. Conclusions: Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects. (Korean J Anesthesiol 2007; 52: 550~5)