Broad Band Ultraviolet B 조사에 의해 유도된 피부 종양에 대한 Poly-gamma Glutamic Acid의 효과 = The Effects of Poly-gamma Glutamic Acid on Broad Band Ultraviolet B-induced Skin Tumors in a Mice ModelBroad Band Ultraviolet B 조사에 의해 유도된 피부 종양에 대한 Poly-gamma Glutamic Acid의 효과

다국어 초록 (Multilingual Abstract)

Background: Poly-gamma glutamic acid (γ-PGA) is a natural polymer that is synthesized by Bacillus subtilis. Because of the reported anti-tumor effect, γ-PGA and its derivatives have attracted enormous interest in the past few years. Objective: The anti-tumor effects of γ-PGA against ultraviolet B (UVB) were evaluated by irradiating hairless mice with UVB. Methods: The experimental animals were 12-week-old male Albino hairless Skh:HR-1 mice. Thirty-two mice were divided into 4 groups: a chronologic aging (control); irradiation with UVB without γ-PGA administration (T1); irradiation with UVB and 2,000 kDa γ-PGA orally (T2); and irradiation with UVB and 5,000 kDa γ-PGA orally (T3). The irradiation period was 12 weeks. The anti-tumor effect of γ-PGA was evaluated with photographs and skin biopsy. A 51Cr release assay was performed to determine nutural killer cell (NK cell) activity. Results: After 20 weeks of UVB irradiation, seborrheic keratosis, actinic keratosis, Bowen`s disease, squamous cell carcinoma, and basal cell carcinoma were observed on the backs of mice. The most common skin lesion was seborrheic keratosis. γ-PGA showed inhibitory effects on the total number of skin tumors and the premalignant and malignant skin lesions induced by UVB. The NK cell activities showed a tendency to increase based on the molecular weight of γ-PGA. Conclusion: We suggest that γ-PGA shows anti-tumor effects that inhibit the tumor generation induced by UVB, and the antitumor effects are related to the molecular weight of γ-PGA. (Korean J Dermatol 2009;47(9):1012∼1018)

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