방광암종의 등급 결정을 위한 컴퓨터를 이용한 분류기 생성에 관한 연구 = Study on Creating A Classifier for Grading of Bladder Carcinoma Based on Computerized Method

다국어 초록 (Multilingual Abstract)

We have described an objective and reproducible classification method for grading malignancy in the Feulgen stained bladder carcinoma. To create an optimized classifier
for malignancy grading of histological bladder carcinoma cell images, it is necessary to extract the features that accurately describe the order/disorder of the nuclear variation and to evaluate the significance of the features. Above all, features selection considered about the correlation of features is very important, because the performance of the classification method depends on the selected features. Methods : First, we acquired 40 representative
histological bladder carcinoma cell images from each of four groups (Grade 1, Grade 2A, Grade 2B, Grade 3) and extracted morphology features, texture features and the texture features of wavelet transformed images. Second, we evaluated the significance of the extracted features using variance analysis. Third, we created classifiers for each selected feature and its combination set using discriminant analysis. Finally, we compared and analyzed the correct classification rate of each classifier. Results : The optimized classifier was created from the combination of morphology features, texture features and the texture features of wavelet
transformed images. Conclusions : We found that the correlation of features is more important
than one feature’s great significance in grading the malignancy of bladder carcinoma,
and we have confirmed that the correct classification rate is determined by feature extraction,
feature evaluation and feature selection.