Uric Acid Level Has a J-Shaped Association with Arterial Stiffness in Korean Postmenopausal Women

다국어 초록 (Multilingual Abstract)

Background: Uric acid has been reported to function both as an oxidant or antioxidant depending on the context.
A previous study in the Korean population reported a positive linear association between serum uric acid level andarterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterialstiffness in Korean postmenopausal women.
Methods: We performed a cross-sectional study of 293 subjects who participated in a health examination programrun by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. Highbrachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s.
The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regressionanalysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk.
Results: The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-anklepulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocityacross the uric acid quartiles were 2.642 (Q1, 1.095–6.3373), 1.00, 4.305 (Q3, 1.798–10.307), and 4.375 (Q4,1.923–9.949), after adjusting for confounding variables.
Conclusion: Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausalwomen.

참고문헌 (Reference)

1 Davies KJ, "Uric acidiron ion complexes : a new aspect of the antioxidant functions of uric acid" 235 : 747-754, 1986

2 Dawson J, "Uric acid reduction: a new paradigm in the management of cardiovascular risk?" 14 : 1879-1886, 2007

3 Odden MC, "Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002" 64 : 550-557, 2014

4 Kanda E, "Uric acid level has a U-shaped association with loss of kidney function in healthy people: a prospective cohort study" 10 : e0118031-, 2015

5 Sautin YY, "Uric acid : the oxidant-antioxidant paradox" 27 : 608-619, 2008

6 Becker BF, "Towards the physiological function of uric acid" 14 : 615-631, 1993

7 Waring WS, "Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers" 38 : 365-371, 2001

8 Shin JY, "Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men" 17 : 37-43, 2012

9 Li YH, "Sex differences in the association between serum uric acid and cardiac mortality in Asian patients with established coronary artery disease: a revisit of the ET-CHD registry in Taiwan, 1997-2003" 68 : 461-, 2016

10 Hakoda M, "Serum uric acid concentration as a risk factor for cardiovascular mortality : a longterm cohort study of atomic bomb survivors" 32 : 906-912, 2005

11 Choi H, "Serum uric acid concentration and metabolic syndrome among elderly Koreans : the Korean Urban Rural Elderly(KURE)study" 64 : 51-58, 2016

12 Yu TY, "Serum uric acid : a strong and independent predictor of metabolic syndrome after adjusting for body composition" 65 : 432-440, 2016

13 Park BJ, "Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score" 412 : 925-929, 2011

14 Conti FF, "Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations" 309 : R1532-R1539, 2015

15 Stachowiak G, "Metabolic disorders in menopause" 14 : 59-64, 2015

16 Meirelles RM, "Menopause and metabolic syndrome" 58 : 91-96, 2014

17 Au A, "Estrogens, inflammation and cognition" 40 : 87-100, 2016

18 Park BJ, "Elevated intraocular pressure is associated with metabolic syndrome in postmenopausal women : the Korean National Health and Nutrition Examination Survey" 20 : 742-746, 2013

19 정동혁, "Association of Renal Manifestations with Serum Uric Acid in Korean Adults with Normal Uric Acid Levels" 대한의학회 25 (25): 1766-1770, 2010

20 Park BJ, "Association between resting heart rate and arterial stiffness in Korean adults" 103 : 246-252, 2010

21 Ama Moor VJ, "Assessment of the 10-year risk of cardiovascular events among a group of Sub-Saharan African post-menopausal women" 23 : 123-131, 2016

22 Boutouyrie P, "Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients : a longitudinal study" 39 : 10-15, 2002

23 Laurent S, "Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients" 37 : 1236-1241, 2001

24 Fuhua P, "Antioxidant status of bilirubin and uric acid in patients with myasthenia gravis" 19 : 43-49, 2012

25 Campesi I, "Ageing/menopausal status in healthy women and ageing in healthy men differently affect cardiometabolic parameters" 13 : 124-132, 2016