정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계 = Hemispheric Asymmetry and Its relationship with Brain Atrophy in Computed Tomography of Schizophrenics

다국어 초록 (Multilingual Abstract)

Since the advent of computed tomography(CT). there have been growing evidences of cerebral structural abnormalities in schizophrenics. Among them. reversed hemispheric asymmetry has been regarded as impaired cerebral lateralization of schizophrenics representing another pathology different from brain atrophy. To investigate the pattern and frequency of reversed cerebral asymmetry and their relationship with brain atrophy. we analyzed widths of frontal and occipital region on the brain CT scans of right-handed 56 schizophrenics and 52 normal controls by a manual method. Brain atrophies were assessed using fixed arm planimetry and visual lineat measurements. Compared to normal controls. the schizophrenics show significantly increased frequency of reversed occipital asymmetry. Dividing the schizophrenics into group according to the evidences of atrophy revealed more reversed occipital asymmetry than those with brain atrophy. These findings suggest that reversed cerebral asymmetry might be unrelated to brain process and would be a neuroanatomic evidence of abnormal asymmetry of schizophrenices.