극심한 원형 탈모증에서의 pulse corticosteroid 치료효과 = Therapeutic rate Pulse corticosteroid in severe alopecia arete

다국어 초록 (Multilingual Abstract)

Extensive alopecia are ka is difficult to treat. Topical immunotherapy is a time consuming with its eczematous dermatitis. Pulse corticosteroid is being used for severe autoimmune diseases, by which a large dose can be given with less side effects. Methylprednisolone pulse therapy was done in 46 cases of extensive alopecia areata and its results were observed for half to seven years. The drug was given three times in average at one to two week interval as intravenous methylprednisolone sodium succinate 25mg/kQ in 180㎖ of 5% dextrose water. Eight patient (17.4%) were recovered without recurrence (Group A). Eighteen (39.1%) were also fully recovered but needed intermittent maintenance therapy with low-dose oral corticosteroid (Group B). Both of above two group (56.5%) showed terminal hair responses uniformly throughout the bald area within 3 months after beginning the therapy. Eleven (23.9%) showed slower response with patchy hair growing, among whom three failed to keep the grown hairs despite of oral corticosteroid maintenance (Group C&D). Nice (19.6%) showed only vellus-hair response (Group E). The common side effects are temporary facial flushing(50%), vaginal spotting(35.7%), mild facial swilling(35%) and acne eruption(19.6). No serious side effect was noted an all the patients were complacent to the procedure.
In conclusion, pulse corticosteroid is worthy to be tried in safety for severe alopecia areata and is highly recommended in the early acute stage of alopecia totalis.

목차 (Table of Contents)

• 목차
• 1. 영문 초록 = 2
• 2. 서론 = 4
• 3. 대상 및 방법 = 5
• 4. 결과 = 8
• 6. 고찰 = 11
• 6. 결론 = 15
• 7. 참고 문헌 = 16