Recently, phospholipase D (PLD) is known to be involved in several bioactive materials-mediated signal transduction pathway. In order to investigate how bradykinin works in renal tissue, we in this study wants to figure out whether bradykinin mediates...
Recently, phospholipase D (PLD) is known to be involved in several bioactive materials-mediated signal transduction pathway. In order to investigate how bradykinin works in renal tissue, we in this study wants to figure out whether bradykinin mediates its physiological actions through activation of PLD or not. Bradykinin, which is a well known neuroactive peptide and plays many important physiological roles as vasodilatation, hyperalgia, has been reported to activate PLD in PC12 cells. As a corollary of our experimental results, we are first group ever to reveal the positive involvement of PLD in bradykinin-mediated signal transduction mechanism in the rabbit kidney proximal tubule cells.