Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T<sub>2</sub>DM). Methods: This was a retrospective observational longitud...
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https://www.riss.kr/link?id=A104186504
2017
Korean
SCIE,KCI등재
학술저널
875-882(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T<sub>2</sub>DM). Methods: This was a retrospective observational longitud...
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T<sub>2</sub>DM).
Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of<sub>349</sub> patients with T<sub>2</sub>DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m<sup>2</sup>) were enrolled. The main outcome was the development of CKD stage 3 or greater. The patients were divided into four groups according to the quartiles of the total serum bilirubin levels at baseline.
Results: The group with the lowest range of total serum bilirubin level (Q<sub>1</sub>) showed the highest cumulative incidence of CKD stage 3 or greater than that of the other lower quartiles (Q<sub>1</sub> vs. Q<sub>4</sub>; hazard ratio [HR], 6.75; 95% confidence in-terval [CI], 1.54 to 29.47; p = 0.011). In multivariate analysis, the risk of developing CKD stage 3 or greater was higher in the second lowest quartile of the serum bili-rubin level than that in the highest quartile of the serum bilirubin level (Q<sub>2</sub> vs. Q<sub>4</sub>; HR, 9.36; 95% CI, 1.33 to 65.73; p = 0.024). In the normoalbuminuria subgroup (n = 236), multivariate analysis showed that the risk of developing CKD stage 3 or greater was higher in the lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q1 vs. Q4; HR, 7.36; 95% CI, 1.24 to 35.82; p = 0.019).
Conclusions: Serum bilirubin might be an early clinical marker for predicting the progression of CKD in patients with T<sub>2</sub>DM and preserved renal function.
Comment on “Gastric cancer and family history”
Solitary immunoglobulin G4-related inflammatory pseudotumor in the abdomen wall