자연과학편 : 중년여성의 혈청 IGF-1, 신체조성, 근력이 국소부위의 골밀도에 미치는 영향 = The influence of Local bone mineral densities by the IGF-1, body composition, muscle strength in the middle-aged women

국문 초록 (Abstract)

본 연구의 목적은 폐경 전 중년여성을 대상으로 IGF-1, 신체조성, 근력 및 국소부위의 골밀도간의 관련성과 국소부위의 골밀도에 독립변인들이 미치는 영향을 구명하는 것이었다. 연구대상자들의 연령은 45.84±4.71세 이었으며, BMI는 24.15±2.71, 체지방율은 30.46±5.94%로 저체중 비만형으로 골밀도에는 다소 부정적인 체형으로 나타났다. IGF-1은 신체조성, 근력 및 국소부위골밀도들과 전혀 유의한 상관이 나타나지는 않았다. 요추부위의 골밀도는 체중((r=0.28-0.40, p<.050), BMI(r=0.31-0.40, p<.03), 체지방율(r=0.39-0.59, p<.001)에서 유의한 상관이 나타난 반면, 대퇴골두 부위의 골밀도들은 체중(r=0.37-0.44, p<.01), BMI(r=0.33-0.40, p<.01), 근육량(r=0.34-0.37, p<.01), 체지방율(r=0.27-0.37, p<.06)과 각각 유의한 상관이 인식되었다. 중다회귀분석 결과, 요추골밀도는 체지방과 완견인력의 조합으로 약 38%의 설명력이 있었으며, 대퇴골두부위 골밀도는 BMI, 근육량, IGF-1의 조합으로 약 18%의 설명력을 나타냈다. 결론적으로 폐경 전 중년여성들의 국소부위의 골밀도는 LBM, 근력, IGF-1에 의한 영향보다는 체지방 요인이 더 크게 작용하는 것으로 인식되었다.

다국어 초록 (Multilingual Abstract)

The purpose in this study was to identify an correlations among IGF-1, body composition, muscle strength, and bone mineral densities in the middle-aged women. The 46 middle -aged women involved volunteerly in this study. There were 45.84±4.71 yrs in age, and 24.15±2.71 with BMI. They were measured the local bone density(lumbar and femur sites) by DEXA method, body composition by BI method, limbs strength with isometric instrument ,and serum IGF-1. The results are below. 1) Physical characteristics in the subjects were low body weight, and high fat type. L1-4 densities were significantly correlated to body weight((r=0.28-0.40, p<.050), BMI(r=0.31-0.40, p<.03), %Fat(r=0.39-0.59, p<.001), respectively. Femur head densities were positively correlated to body weight(r=0.37-0.44, p<.01), BMI(r=0.33-0.40, p<.01), muscle mass(r=0.34-0.37, p<.01), % Fat (r=0.27-0.37, p<.06). Stepwise multiple regression indicated that %fat and arm rowing strength together explained 38% variance of L1-4 BMD, and BMI, muscle mass, IGF-1 together explained 18% variance of femur head BMD. In conclusion, the local BMD in the middle-aged women had greater influence on the fat mass than those of the LBM and strength.

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