In vivo Optical Coherence Tomography Imaging of the Mesothelium Using Developed Window Models

다국어 초록 (Multilingual Abstract)

The mesothelium is an essential lining for maintaining the normal homeostasis of the closed body cavityand a central component of pathophysiologic processes. The mesothelium has been known as the end targetfor asbestos which induces asbestos-related lung diseases. Malignant mesothelioma (MM) is a rare andfatal neoplasm predominantly due to asbestos exposure. Adaptation of an advanced and reliable technologyis necessary for early detection of MM because it is difficult to diagnose this disease in its early stages.
Optical coherence tomography (OCT) provides cross-sectional images of micro-tissue structures with aresolution of 2-10 μm that can image the mesothelium with a thickness of ~100 μm and, therefore, enableinvestigation of early development of MM. The mesothelium is typically located at the pleura and tunicavaginalis of the scrotum. In this study, we developed animal window models in the above two anatomicalsites to visualize mesothelial layers within the mesothelium. OCT images at the two locations were alsoacquired

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