Clinical Parameters Related to the Duration of Automatic Positive Airway Pressure Titration

다국어 초록 (Multilingual Abstract)

Background and Objective Automatic positive airway pressure (APAP) therapy is a treatment and titration method for obstructive sleep apnea (OSA). However, little is known about the optimal duration of APAP titration for identifying effective pressure. 1) To evaluate the response of patients with OSA to low-span APAP titration for up to 3 months; 2) to find the optimal duration of APAP titration necessary to achieve the lowest treatment pressure; and 3) to identify variables that affect the APAP titration.
Methods This retrospective study was done in a single tertiary-care academic medical center. It included 50 patients with low-span APAP treatment from January 2016 to December 2018. The patients were divided into low-variation and high-variation groups depending on the median value (18%) of change in the apnea–hypopnea index (AHI) from 1 week to 1 month.
Results The AHI estimated by the APAP machine showed different features over time in each group and changed significantly even after a month. The change in AHI was greater in patients with a larger forced vital capacity (FVC) (> 92.5% predicted value) of a pulmonary function test, and was lesser in older (> 52 years) patients. This change was also compared with body composition between the two groups.
Conclusions Final titration pressure may be established at approximately 1 month after APAP titration. In particular, for patients with larger FVCs, it may be necessary to further adjust the treatment pressure to a minimum to improve compliance.

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