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종양치료시 항종양제에 의한 조혈기 장애에 대한 Cephalanthin^(R)의 임상적 평가
김영일,노승무,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
The clinical effect of Cephalathin Tab^(R). was observed in 33 cases with chemotheraphy in the cancer patients. Cephalathin Tab^(R). was administered per oral 3-6mg daily in three divided for an average of 58 days. The overall effectiveness was 87% and there was no side effect of Cephalathin Tab^(R). In conclusion, Cephalatin Tab^(R). was safe and effective drug for management of hematologic disorder by the anticancer agent.
만성 동맥 폐색증 환자에서 Cilostazol(Pletaal^�)투여시 자각증상 및 혈액 동태에 미치는 영향
김영일,노승무,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1
At department of Surgery, Chungnam National University Hospital, from March 1991 to October 1991, a new platelet aggregation inhibitor, cilostazol, with a vasodilating action, was administered orally in daily doses of 200mg for 8 weeks in chronic arterial occlusive diseases. After administration, the clinical effects of cilostazol were observed in 10 patients with thromboangiitis obliterans and arteriosclerosis obliterans. The results were as follows: 1. The overall improvement rate of the diseases was 80 percent. 2. The adverse effects of cilostazol were headache in one patient, indigestion in one patient, and overall safety rate was 80 percent. It can be concluded that cilostazol is useful in the treatment of chronic arterial occlusive disease.
선천성 거대결장증 진단에 필요한 조직화학염색 : Rapid Acetylcholinesterase Staining
설지영,김제룡,김진만,장일성 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
Hirschsprung's disease is a congenital absence of ganglion cells in the Meissner's and Auerbach's plexuses of the colon. The definitive diagnosis of the disease can only be based on histologic examination of bowel wall biopsies demonstrating aganglionosis. To distinguish Hirschsprung's disease from other causes of contipation and megacolon, it is helpful to use histologic examination with routine hematoxylin and eosin (H&E) staining and acetylcholinesterase (AChE) special histochemical staining techniques. With H&E staining, the difficulties may arise in the hypoganglionic area of the transition zone, or in hypoganglionosis or neuronal intestinal dyspiasia. The AChE technique provides reliable identification of ganglion cells by staining nerve filaments in close proximity to the ganglion cells. However, the conventional AChE technique takes about 2 hours for the examination of specimens, so it is not suitable for intraoperative examination. Using a rapid AChE histochemical staining technique, it is possible to produce staining of cholinergic fibers in 20 minutes. It should enable the surgeon to use it selectively during operation and to support or refute the H&E findings.
장일성,김영일 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2
This report is a clinical review of 50 cases of early gastric cancer that were treated and followed during 6 years from June. 1985 to June 1990. 1. The peak incidence age was 50 decade(38%), the mean age was 50 years, the ratio of male to female was 3:2. 2. The preoperative diagnostic rate was 52% by double conrast and 60% by endoscopy and biopsy. 3. The most common size of lesions was 1.1-2cm(32%) the smaller of lesion, the greater incidence of invasion rate to submucosa but no relation to lymph node matastasis rate. 4. The most common type of lesion was IIc(28%), the depressed type(III, IIb+c, IIc) was lymph node metastasis, but the elevated type and flat type was not lymph node matastasis. 5. The most common histological type was moderate differentiated and signet-ring cell types(32.5%) the most common type of metastatic rate was moderate differentiated type (30.7%), the badder of differentiated type, the greater incidence of metastatic rate to lymph node. 6. The common sites were lower third and lesser curvature(50%). The greater incidence of metastatic rate and invasion rate to submucosa the site of posterior wall was. 7. The rate of lymph node matastasis was 6.3% in mucosa, 26.4% in submucosa and 20% in total. 8. Follow up studies were possible in 45 cases, in these 1 case was died, 1 case was recurred but alive.
위장관 수술후 소화 불량증상을 호소하는 환자에 종합소화효소제 베아제정의 임상효과
손기섭,배진선,장일성,윤완희,김영일 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2
The Clinical effect of Bearse Tab. was observed in 58 cases with postoperative indigestion. The results were as follows : 1. Overall evaluation of treatment revealed effective in 80.9% (34/42) after the GI surgery, improvement rate were 77.8%(23/31). 2. At the postoperative abdominal distention, improvement rate were high rate (92%). 3. There was no side effect of Bearse Tab. In Conclusion, Bearse Tab was safe and effective for management of postoperative indigestion state.
김진희,이충식,배진선,조준식,임의혁,정현용,김영건,이헌영,육은주,김성걸,노승무,장일성 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.2
In order to decide on appropriate treatment strategy against gastric cancer, an accurate preoperative evaluation of the depth of cancer invasion is essential. We studied 165 cases(19%) of early gastric cancer among 706 cases of gastric cancer. resected over a 6 year period. A retrospective study of early gastric cancer was done to evaluate the endoscopic accuracy and lymph node metastasis status, the following results were obtained: 1) The proportion of EGC according to macroscopic type was 68.5% of depressed type(II, III, IIa+III, IIc+III, III+IIc, IIb+IIc), 26% of elevated type(I, IIa, IIa+ IIb, IIa+IIc), 5.5% of flat type(IIb). 2) In the view of accuracy of endoscopic diagnosis, the rate of accurate diagnosis suitable for postoperative macroscopic type was 37.5%, the rate of unsuitable typed EGC was 33.3%, overestimation(diagnosed to AGC) was 20.6% and underestimation(diagnosed to benign diseases)was 8.6%. Overall accuracy of endoscopic diagnosis was 70.8%. 3) The cases confined to the mucosa were 40.6% and others were submucosal cancers(59.4%). 4) Positive lymph node metastasis was found in 1.5% of M-cancer and 18.4% of SM-cancer(overall 11.5%). 5) Node positive rate of differentiated cancer was 10.5%, undifferentiated carcinoma was 15.4%. There was no signficant difference in frequency of nodal metastasis according tumor size and macroscopic type. 6) Tumors which satisfy the following criteria may not metastasize to lymph nodes:(1) confined to the mucosa; (2) less than 2.0cm in diameter; (3) macroscopically elevated or flat; (4) histologically well or moderately differentiated.
유방암 수술 환자의 추후관리를 위한 베하스[BeHaS] 프로그램이 자아존중감, 피로와 불안에 미치는 영향
김종임(Kim Jong Im),민효숙(Min Hyo Suk),박선영(Park Sun Young),김선애(Kim Sun Ae),전영숙(Jun Young Suk),임정선(Lim Joung Sun),김소현(Kim So Hyun),장일성(Chang Eil Sung) 기본간호학회 2009 기본간호학회지 Vol.16 No.3
Purpose: The purpose of the study was to identify effects of the BeHaS program on self esteem, fatigue and anxiety in postoperative care patients with breast cancer who had surgery with, chemotherapy, radiotherapy, with or without current hormone therapy. Methods: This study was a 2-group quasi-experimental research study with a pre and post test design. Fifty-four patients with breast cancer were assigned to the experimental (n=29) or control group (n=25). The BeHaS program which strengthens self esteem through support over a 90-minute period, consists of theme activity (30 minutes), education (15 minutes), group support (15 minutes) and exercise (30 minutes). The experimental group participated in the program once a week for 10 weeks, but the control group was not involved. Data were gathered from October to December, 2008 using a questionnaire with measures of self esteem, fatigue and anxiety. Data were analyzed using t-test with SPSS Win 12.0 to identify differences between the groups. Results: Self esteem was significantly increased (p= .001) and fatigue significantly decreased (p= .013) in the experimental group. But there was no significant difference in anxiety (p= .868). Conclusion: These results suggest that the BeHaS program for patients with breast cancer had beneficial effects on self esteem and fatigue.