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( Jing Wu ),( Xin Yu Tan ),( Xiao Zhong Peng ),( Jian Gang Yuan ),( Bo Qin Qiang ) 생화학분자생물학회 2003 BMB Reports Vol.36 No.4
For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells. Immunostaining indicated that CacyBP was present in the cytoplasm of uninduced SH-SY5Y cells, in which the resting Ca^(2+) concentration was relatively lower than that of RA-induced cells. After the RA induction, immunostaining was seen in both the nucleus and cytoplasm. In the RA-induced differentiated SH-SYSY cells, CacyBP was phosphorylated on serine residue(s), while it existed in a dephosphorylated form in normal (uninduced) cells. Thus, the phosphorylation of CacyBP occurs when it is translocated to the nuclear region. The translocation of CacyBP during the RA-induced differentiation of SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation.
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Wu, Jing,Tan, Xinyu,Peng, Xiaozhong,Yuan, Jiangang,Qiang, Boqin Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.4
For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells. Immunostaining indicated that CacyBP was present in the cytoplasm of uninduced SH-SY5Y cells, in which the resting $Ca^{2+}$ concentration was relatively lower than that of RA-induced cells. After the RA induction, immunostaining was seen in both the nucleus and cytoplasm. In the RA-induced differentiated SH-SY5Y cells, CacyBP was phosphorylated on serine residue(s), while it existed in a dephosphorylated form in normal (uninduced) cells. Thus, the phosphorylation of CacyBP occurs when it is translocated to the nuclear region. The translocation of CacyBP during the RA-induced differentiation of SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation.
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Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors
Wu, Bai-Shou,Hu, Yi,Sun, Jing,Wang, Jin-Liang,Wang, Peng,Dong, Wei-Wei,Tao, Hai-Tao,Gao, Wen-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Objective: To retrospectively review the clinical characteristics and analyze the prognostic factors of Chinese patients with pulmonary neuroendocrine tumors. Materials and Methods: The clinical data of 176 patients with pulmonary neuroendocrine tumors in Chinese PLA General Hospital from Mar., 2000 to Oct., 2012 were retrospectively analyzed. The parameters were evaluated by univariate and multivariate analysis, including the gender, age, smoking history, family history, TNM staging, localization (central or peripheral), tumor size, nodal status, histological subtype and treatment (operation or non-operation). Results: There were 23 patients with typical carcinoids (TC) (13.1%), 41 with atypical carcinoids (AC) (23.3%), 10 with large cell neuroendocrine carcinoma (LCNEC) (5.7%) and 102 with small cell lung cancer (SCLC) (57.9%). The median follow-up time was 64.5 months for AC, 38 months for LCNEC and 27 months for SCLC. The typical carcinoid censored data was 18 (more than 50% of the patients), so the median follow-up time was not obtained, and actuarial 5-year survivals for TC, AC, LCNEC and SCLC were 75.1%, 51.7%, 26.7% and 38.8%, respectively. COX univariate analysis revealed that the age (P=0.001), histological subtype (P=0.005), nodal status (P=0.000), treatment (P=0.000) and TNM staging (P=0.000) were the prognostic factors of the patients with pulmonary neuroendocrine tumors, whereas its multivariate analysis showed that only the age(P=0.001), TNM staging (P=0.002) and treatment (P=0.000) were independent prognostic factors. Conclusions: Radical surgery remains the treatment of choice, and is the only curative option. The age, TNM staging and treatment are confirmed to be the independent prognostic factors in multivariable models for pulmonary neuroendocrine tumors.
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Wen-wu Huang,Xiaobo Li,Meng Yue Wang,Hai-ming Shi,Ying Peng,Chong-sheng Peng,Min Zhang,Yue Li,Jing Lu 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
Two HPLC methods with diode array detection (HPLC-DAD) and electrospray ionization-mass spectrometry (HPLC-ESI/MS), respectively, were developed to investigate the differences of chemical constituents and their metabolism in gastrointestinal tract in vitro between two decoctions of crude and processed Glycyrrhizae radix. Total of eleven constituents (liquiritin apioside, liquiritin, licuraside, isoliquiritin, ononin, glycyrrhizin, liquiritigenin-7,4'-diglucoside, licorice saponin A3, 22β-acetoxylglycyrrhizic acid, licorice saponin G2, and yunganoside E2) were identified in the two decoctions, whereas lower contents of these constituents were usually found in the decoction of processed G. radix. Furthermore, these constituents were metabolized into their respective aglycons in human intestinal bacteria juice, and the metabolism ratios were all higher in processed G. radix decoction. No change was found in artificial gastric or intestinal juice. This study revealed that the processing can alter the contents of main constituents in crude G. radix and their metabolism in gastrointestinal tract, in which intestinal bacteria play an important role in the metabolism of licorice constituents.
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Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.
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The Characteristics and Distribution of Eukaryotic Phytoplankton Community in Liaodong Bay, China
Lun Song,Jing Wu,Jing Du,Nan Li,GuangJun Song,Kun Wang,Ming Sun,Peng Wang 한국해양과학기술원 2019 Ocean science journal Vol.54 No.2
Brown tides have occurred in the Bohai Sea of China since 2009 and caused serious losses in aquaculture. In recent years, phytoplankton identification has been greatly promoted by the development of high-throughput sequencing technologies. In this study, V4 region of 18S rDNA was used as the target gene to design the primer V4 (F/R), and high-throughput sequencing technology was adopted to evaluate the diversity of composition and characteristics of the eukaryotic phytoplankton community. A total of 93 alga species were identified, and about 60% (56 out of 93) of them were undetected or unreported in Chinese waters. There were 59% of the total algal species identified as autotrophy in trophic mode while heterotrophy and mixotrophy accounted for 12% and 29% of the total algal species, respectively. 8 species of picophytoplankton that were mainly distributed in the south and a partial area of the east and west formed the scientific basis for the quality and safety early-warning in aquatic products and brown rides study. Diversity index analysis also revealed a trend of fluctuations of marine phytoplankton diversity in different sample sites in Liaodong Bay. In conclusion, our work provides a detailed evaluation of eukaryotic phytoplankton diversity in Liaodong Bay, suggesting the need for long-term monitoring to further study and guard against the potential risk of harmful algal blooms.
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Dapeng Li,Peng Zhang,Jiangtao Duan,Yaxin Wu,Na Ding,Zhenyu Wan,Longqi Chen,Jingli Xu,Suxiang Ge,Juntao Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Utilization of fly ash (FA) wastes as the carriers of catalysts for the environmental application is an economicand practical strategy for their low cost, easy accessibility and thermal stability. However, mostcatalysts immobilized on fly ash were metal or metal oxides, some potential catalysts such as metalphthalocyanine complexes have not been reported upon their heterogeneous catalysis with FA as the carriers. In this paper, highly active iron octacarboxyphthalocyanine were immobilized onto the bird nestlikesurfaces of fly ash microspheres after NaOH activation. It is noted that the FeOCPc@FA compositeswith only 2 wt.% exhibited the high catalytic efficiency in the organic dye degradation. The high concentrationof 30 mg/L rhodamine B and methylene blue could be fast decolorized in the presence ofFeOCPc@FA–2 % and KHSO5. Moreover, the ultrafast decolorization of these dyes could be observed inthe catalytic system composed of FeOCPc@FA–2 %, KHSO5 and BuOOH (tert-butyl hydroperoxide). Simultaneous activation of KHSO5 and BuOOH could be realized in our designed catalytic system. Based on the structural characterizations of composites and active species generated during the catalyticprocesses, the probable generation pathway of metal–oxygen active species and various radicals wereanalyzed to explicate the catalytic mechanism. Our investigation provides a high efficiency, low costand environmentally friendly strategy for advanced oxidation treatment of organic pollutants.
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( Yi Guang Wu ),( Zhe Jin ),( Zhong Cheng Xin ),( Wei Dong Song ),( Jing Peng ),( Zhi Chao Zhang ),( Bing Gao ),( Ze Long Kim ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.4
The purpose of this experiment is to construct an in vitro model of rabbit penis enlargement using tissue engineering method, and to investigate the efficacy and safety of autologous fibroblast cell seeded to biodegradable scaffold and also to provide a new perspective of clinical application. We observed the growth of GFP transgenic fibroblast cell from SD mouse after transplantation with the biodegradable scaffold by fluorescence microscope. At the second hand, 160 male New Zealand rabbits were divided into four groups; Group A for control; Group B for acellular matrix implanted; Group C for scaffold implanted only; Group D for autologous cultured fibroblast seeded scaffold. Rabbit scrotal skin (4×4 mm) was detached under general anesthesia, and fibroblast (FB) was cultured and proliferated for 2weeks. Cultured cells were seeded into the scaffold and inserted on the between buck`s and dartos fascia of rabbit penis. To assess the efficacy and safety of the cells, we observed for 4months. The FB of rabbit were successfully cultured and confirmed by immunohistochemistry method. In the results of group D, dermal cell seeding group, the penile girth was significantly increased to 22.3% compared to other groups (Group A 0.3%, Group B 12.7%, Group C 14.6% and Group D 22.3%). We checked the results in 2~4 months later. We observed that moderate penile girth increase was gained using the biodegradable scaffold without other side-effects. Therefore, we carefully suggest a new guidance for penile augmentation by the tissue engineering method.
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