급성 골수성 백혈병 환자에서 관해 유도 항암 화학요법 후 발생한 베르니케 뇌증

황진원,정재현,서광원,최병진,송영진,김종윤,이은지,임홍규,이상민 인제대학교 2009 仁濟醫學 Vol.30 No.-

Wernicke's encephalopathy is characterized by the triad of ocular symptoms, ataxia, and mental confusion and neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, hyperemesis gravidarum, anorexia nervosa, hemodialysis, uremia, and acquired immunodeficiency syndrome(AIDS). Chemotherapy in patient with malignanacy and long term total parenteral nutrition following bone marrow transplantation are related with Wernicke's encephalopathy. A 48-year-old woman had been treated with Daunorubicin and Cytarabine for remission induction chemotherapy of acute myeloblastic leukemia and intravenous hyperalimentation due to persistent hematochezia and ileus caused by infiltration of leukemic cell in terminal ileum. She suddenly complained of diplopia, tremor, and mental confusion at 32th day after chemotherapy and generalized tonic-clonic seizure at 34th day after chemotherapy. The diagnosis of Wernicke's encephalopathy was made with clinical presentations and brain MRI. Brain MR T2-weighted & Flair image revealed a high signal intensity lesions bilaterally at the medial thalamus and peri-acueductal grey matter of the midbrain. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after remission induction chemotherapy followed by intravenous hyperalirnentation in a patient with acute myeloblastic leukemia.

Improvement and Application for Environmental Conservation Value Assessment Map (ECVAM) of Nationwide Land in Korea

Moung Jin Lee,Seong Woo Jeon,Min Jeong Jo,Won Kyong Song,Byung Jin Kang 大韓遠隔探査學會 2007 大韓遠隔探査學會誌 Vol.23 No.5

This study is aiming at improving the Environmental Conservation Value Assessment Map (ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4 % of diameter Grade II (standard for stability); forest diameter item accounted for 99.9 % by Method 3, Method 4 showed 95.7 % of forest diameter, and forest density accounted for 66.4 % by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.

Improvement and Application for Environmental Conservation Value Assessment Map(ECVAM) of Nationwide Land in Korea

Lee, Moung-Jin,Jeon, Seong-Woo,Jo, Min-Jeong,Song, Won-Kyong,Kang, Byung-Jin The Korean Society of Remote Sensing 2007 大韓遠隔探査學會誌 Vol.23 No.5

This study is aiming at improving the Environmental Conservation Value Assessment Map(ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4% of diameter Grade II(standard for stability); forest diameter item accounted for 99.9% by Method 3, Method 4 showed 95.7% of forest diameter, and forest density accounted for 66.4% by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.

전두사골 수막뇌류 및 Saethre-Chotzen증후군에 의한 안와격리증의 치험

송중원,한기환,박성근,강진성 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

본 교실에서는 전두사골 수막뇌류에 의한 안와격리증 2례는 두개내 접근으로 수막뇌류 절제술을 실시함과 동시에 두 개외 접근으로 안와내벽 및 외벽 절골술로써 교정하였으며 Saethre-Chotzen 후군에 의한 1례는 두개골 성형술과 U형 절골술로 교정하여 비교적 만족할 만한 결과를 얻을 수 있었기에 보고하는 바이다. The authors experienced two cases of mild hypertelorism with frontoethmoidal meningoencephalocele and one with Saethre-Chotzen syndrome. The first and second cases, which had nasofrontal and nasoethmoidal meningoencephalocele respectively, were corrected by resection of the meningoencephalocele, repair of the dura, and calvarial bone graft intracranially, and combined medial and lateral orbital wall osteotomy with augmentation rhinoplasty with calvarial bone grafts extracranially. To stabilize the orbital contents medially, a split osteotomy of the lateral orbital wall and interpositional bone graft were done in order to avoid step deformity of the lateral orbital rim. The third case, Saethre-Chotzen syndrome characterized brachycephaly, hypertelorism, ptosis of the eye lid, maxillary hypoplasia, lower set frontral hair line, and partial cutaneous syndactyly was corrected by a Modified Marchac technique for remodelling the forehead and a subcranial U-osteotomy for mild hypertelorism. Maxillary hypoplasia was corrected effectively by advancement on the medial portion of the U-shaped bony segment. Augmentaton rhinoplasty with calvarial bone graft and chip bone grafts on the anterior nasal spine was done simultaneously. A large amount of nasal bone grafts in two cases were absorbed, and then augmentation rhinoplasty using silicone implant was performed after 6 months, 12 months respectively. In mild hypertelorism with associated deformity, a extranial osteotomy with augmentation rhinoplasty and correction of associated deformities can offer good aesthetic results.

Fe-27.5 at.% Al 금속간 화합물의 변형거동에 미치는 변형율 속도의 영향

송진화,하태권,장영원 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.11

The effect of strain rate on the room temperature deformation behavior of a Fe-27.5 at.% Al has been investigated in this study. Phase composition and degree of order in Fe-27.5 at.% Al alloy were varied by aging at various temperatures corresponding to phase fields of D03 and B2 to elucidate the effects of microstructure and degree of order on the room temperature deformation behavior. A series of load relaxation tests was conducted and the results were analyzed based on the internal variable theory of inelastic deformation. Room temperature strength of the Fe-27.5 at.% Al alloy was found to increase with decrease in degree of order. All the flow curves could be successfully described by the constitutive equations of the internal variable theory of inelastic deformation and were found to be governed by the frictional stress element. (Received June 20, 2004)

Hantavirus Pulmonary Syndrome : An Emerging Zoonosis in the New World

송진원 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.2

1994∼1995년 한국에서 발생한 가을철 열성질환에 대한 혈청역학적 연구

송기준,송진원,백락주,김상현,김세연,이용주 대한감염학회 1998 감염 Vol.30 No.4

목 적 : 최근 우리나라에서 발생했던 금성 열성질환의 전반적인 혈청역학적 양상의 분석을 위해 1994년부터 1995년까지 고려대학교 의과대학 미생물학교실, 바이러스병연구소에 급성 열성질환으로 검사가 의뢰된 환자혈청 5330건을 쯔쯔가무시병, 발진열, 신증후출혈열, 라임병 및 랩토스피라증에 대한 항체를 조사하였다. 방 법 : 1994년부터 1995년까지 2년간 고려대학교 의과대학 미생물학교실, 바이러스병 연구소에 검사가 의뢰된 환자혈청을 주 대상으로 간접면역형광항체법 검사로 쯔쯔가무시병, 발진열, 신증후출혈열 및 라임병에 대한 항체양성 유무를 검색하고 macroscopic agglutination법으로 렙토스피라증에 대한 항체를 조사하였다. 결 과 : 열성질환 환자 혈청 5330건을 대상으로 신증후출혈열, 쯔쯔가무시병, 발진열 및 라임병에 대한 항체검사 결과 쯔쯔가무시 항체양성자가 12% (640/5330)로 항체양성자 중 여자가 60%로 60대가 30% (192명)로 가장 많았다. 월별 분포에서는 대부분의 양성자 (89%)가 가을철에 집중되어 있었다. Richettsia, typhi에 대한 항체를 양성률을 보였다. 발진열 항체 양성자 중 남자가 60% (106/178)로 여자보다 많았으며, 모든 연령 층에서 발견되었으나 40∼50대가 57% (107명)로 가장 많았다. 대부분이 양성자 (44%)가 늦가을 (10∼12월)에 발생하였다. Macroscopic agglutination법에 의한 렙토스피라에 대한 항체률을 조사한 결과 1% (55/5330)의 항체 양성률을 보였으며 연도별로는 1994년 0.4% (11/2799), 1995년 1.7% (44/2531)로 1995년에 더 많은 항체 양성자가 발생하였다. 총 55건의 렙토스피라 항체양성자 중 남자가 71% 였으며, 연령별 분포에서는 60대가 47%로 가장 많았으며 20대 이상의 성인에서만 항체가 발견되었다. 대부분의 항체양성자 (78%)가 8∼10월에 집중되었다. 라임병은 총 5330건 중 항체양성자는 없었다. 결 론 : 1994∼1995년 우리나라에서 발생한 발열성질환환자 중 쯔쯔가무시병, 발진열, 신증후출혈열 및 렙토스피라증 환자가 전체의 29%였으며 항체 양성자수로는 신증후출혈열,쯔쯔가무시병,발진열,렙토스피라증 순이였다. 따라서 위의 4가지 질환이 우리나라에서 특히 가을철에 발생하는 급성열성질환의 주원이으로 생각되나 새로운 질병이나 신종 병원체에 의한 동일한 질환이 존재할 가능성이 매우 높으므로 지속적인 혈청역학적 조사가 수행되어야 할 것이다. Background :The principal acute febrile diseases reported in autumn, Korea, have been hemorrhagic fever with renal syndrome (HFRS), scrub typhus, murine typhus and leptospirosis. Methods : To evaluat the seroepidemiologic patterns of acute febrile illness in Korea, sera were collected from 5330 patients from 1994 to 1995, and examined for antibodies against Hantaan virus, Orientia tsutsugamushi, Rickettsia typhi, and Borrelia burgdorferi by indirect immunofluorescent antibidy technique (IFA) and by macroscopic agglutination test for Leptospira interogans. Results : Of 640 seropositive cases against O. tsutsugamushi, 60% were female; age group of the seventh decade occupied 30%; 89% were reported during October and November. By IFA test, the seropositive rate of murine typhus was 3.5% (18/5330) with high incidence rate (44%) in the period from October to December, and males in their forties and fifties were mostly affected. Cases seropositive for leptospirosis consisted 1% of 5330 acute febrile illness cases. Of 55 seropositive cases, 71% were male; 71% were in their sixties; 78% occurred during the period from August to October to January and males in the thirties were mostly infected. No seropositive case of Lyme disease was present. Conclusion : The above results indicate that hantavirus, O. tsutsugamushi, R. typhi, and L. interogans were the main causative agents of acute febrile diseases during autumn season in Korea.

신대륙 한타바이러스 : 한타바이러스 폐증후군 병원체들의 분자생물학적 진화와 계통발생학적 연관성

송진원 대한감염학회 1997 감염 Vol.29 No.2

1993년 한티바이러스 폐증후군 갑작스런 유행의 원인이 무엇인지 그리고 11세 미만의 어린이에서는 한타바이러스 폐증후군 환자가 발생하지 않는 정확한 이유 역시 밝혀져야 할 과제이다. 또한 SN 와 NY 바이러스 감염시에는 매우 드문 신부전증이 어떻게 BAY, BCC 및 Andes 바이러스의 감염시에는 증가하는지 등 한타바이러스 폐증후군의 임상증상 및 그 병인론에 관한 연구도 시급한 실정이며 이를 위해서는 한타바이러스 감염시 사람과 비슷한 증상을 나타내는 적당한 동물모델의 개발이 하루 빨리 선행되야 하겠다.

임베디드 시스템에서 Mobile IP 프로토콜 구현

宋東勳,裵振勝,鄭燦赫,吳世德,李基源,劉忠烈,河載承,李光培,金玄郁 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

With rapid growth of the internet, need for the mobile communication networks is increasing. In this paper, we implement and test Mobile IP Protocol in Embedded System. Our Mobile IP-based testbed consisted of two sub-networks and each sub-network was configured to operate independently through use of router. To satisfy integrated wired/wireless network model established on the testbed design and show generality of the testbed, we implemented mobile nodes, home agent, foreign agent and router on the basis of Linux operating system. As the results of the evaluation, we confirmed that mobile nodes operated properly according to Mobile IP Protocol.

직장암에서 자율신경보존술후 배뇨기능의 변화에 대한 요역동학적 연구

조원상,이상전,송영진 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.4