뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

한국인 정신분열병과 양극성 기분장애에서 Ciliary Neurotrophic Factor(CNTF)유전자 변이에 관하여

이충숙,신석철,지익성,왕성근,이영호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

정신분열병과 양극성 기분장애 같은 주요 정신질환의 발병에서 유전적 요인이 중요하게 작용한다. 최 근 정신분열병과 양극성 기분장애의 원인을 신경병리학적 연구와 신경영상학적 연구를 통하여 신경발달 학인 면에서 이해하려고 시도하고 있다. Ciliary neurotrophic factor(CNTF)는 해마신경원와 내측 중 격신경원을 포함한 다양한 신경세포의 강력한 생명 유지인자로 작용하여 중추신경계의 발달과 유지와 관련이 있는 것으로 여겨지면서, 주요 정신질환의 원인적인 요인으로 제시되고 있지만 이에 대한 연구결 과는 일치되지 못한 상태이다. 이에 저자 등은 한국인 정신분열병 환자 112명과 양극성 기분장애 환자 81명 그리고 정상 대조군 125명을 대상을 CNTF 유전자 변이와 연관성을 알아보고자 본 연구를 시행하여 다음과 같은 결론을 얻었다. CNTF의 유전자형은 정신분열병 환자군에서 N/N 80(70.4%), N/M 32(28.6%), M/M 0(0.0%)이 었고, 양극성 기분장애 환자군에서 N/N 58(71.6%), N/M 23(28.4%), M/M 0(0.0%)이었으며, 정상 대조군에서는 N/N 94(75.2%), N/M 30(24.0%), M/M 1(0.8%)이었다. 대립유전자의 빈도는 정신분 열병 환자군에서 N 192(85.7%), M 32(14.3%)이었고, 양극성 기분장애 환자군에서는 N139(85.8%), M 23(14.2%)이었으며, 정상 대조군에서는 N 218(87.2%), M 32(12.8%)이었다. 3군간의 유전자형과 대립유전자에서 유의한 차이가 없었다. 이러한 연구결과 한국인 정신분열병과 양극성 기분장애에서 CNTF 유전자의 변이가 원인적 요인으 로 작용할 것이라고 볼 수 없었다. Genetic factors play an important role in the development of schizophrenia and bipolar disorder, and recently the neural maldevelopment hypothesis is suggested by neuropathological and neuroimaging studies. Neurotrophic factors, including ciliary neurotrophic factor(CNTF), play a central role in the regulation of neural development. This study was designed to investigate the association between the null mutation of CNTF gene and schizophrenia and bipolar disorder in a Korean population. The CNTF gene were typed with polymerase chain reaction in 112 patients with schizo-phrenia, 81 with bipolar disorders and in 125 healthy controls. The distributions of the CNTF genotype in schizophrenic patients with N/N, N/M, M/M were 80(71.4%), 32(28.6%), 0(0%), in bipolar disorders were 58(71.6%), 23(28.4%), 0(0%) and in the controls were 94(75.2%), 30(24.0%), 1(0.8%). The allele frequencies of the CNTF gene in schizophrenic patients with N and M were 192(85.7%), 32(14.3%), in bipolar disorders were 139(85.8%), 23(14.2%), and in the control were 218(87.2%), 32(12.8%). There were no differences in the genotype distributions and the allele frequencies of CNTF gene null mutation among the 3 groups. These results suggest CNTF gene null mutation is not causally related to the development of schizophrenia and bipolar disorder in Korea.

Amphotericin B의 投與가 마우스의 免疫反應에 미치는 影響

李正鎬,黃翼根 全北大學校 1983 論文集 Vol.25 No.-

Amphotericin B(AmB)가 免疫反應에 關與하는 機轉을 究明하기 爲한 基礎資料를 얻고자 마우스를 모델로 抗原(SRBC)의 感作量, AmB의 投與時期 및 投與量에 따라 AmB가 細胞性免疫反應에 미치는 效果를 足蹠腫腸反應檢査 및 脾臟細胞의 로젵 形成能儉査로 測定하였던 바 다음과 같은 結果를 얻었다. 抗原感作(10^8SRBC/mouse)과 同時에 여러 濃度의 AmB를 投與한 後 發顯되는 DTH는 AmB를 350㎍Υ mouse의 濃度로 投與한 群에서 가장 顯著한 增加를 보였다. 여러 濃度의 感作抗原下에서의 Arthus反應이나 DTH는 모두 投原量에 關係없이 AmB(350㎍/mouse)를 投與한 群에서 對照이 比하여 大體로 增加되었으며, 對照群에서의 最適感作抗原量은 10^7SRBC/mouse이었으나, AmB를 投與한 群에서는 10^8SRBC/mouse이었다. AmB(350㎍/mouse)의 投與時期에 따른 感作抗原(10^8SRBC/mouse)에 對한 DTH는 AmB를 感作 後投與한 群에서는 對照에 比하여 差異ffm 보이지 않았으나 AmB를 抗原感作 前 또는 感作과 同時에 投與한 群에서는 對照에 比하여 DTH가 增加되었는데 特히 AmB를 抗原感作과 同時에 投與한 群에서 그 報加가 가장 顯著하였다. AmB(350㎍/mouse)의 投與時期에 따른 感作마우스(10^8SRBC/mouse)의 로젵 形成率AmB를 抗原 感作前에 投與한 群에서는 對照에 比하여 오히려 減少되었으나, AmB를 抗原感作과 同時 또는 感作 後에 投與한 群에서는 對照에 比하여 增加되었는데 特히 抗原感作 後 4日에 AmB를 投與한 群에서 그 增加가 가장 顯著하였다. 以上의 結果로 AmB가 免疫反應을 增强시키는 最適感作抗原濃度, AmB의 最適投與量 및 投與時期 等을 밝힐 수 있었으며, AmB가 免疫反應에 關與하는 몇가지 可能性있는 機轉을 類推할 수 있었다. Amphotericin B (AmB), a polyene antibiotic that binds to choresterol in the plasma membrane of eukaryotic cells, is clinically used in the treatment of systemic fungal infection. Using in vitro and in vivo models, several investigators have demonstrated both immunostimulatory and immunosuppressive effect of AmB. The immunostimulatory effect of AmB may be a useful adjunct to host defenses against fungi, while the immunosuppressive activity may have deleterious effects. But there has still been no report to evaluate the effects of AmB on delayed hypersensitivity (DTH) and rosette forming cell reaction (RFR). Therefore, this present study was attempted to investigate the immunomodulating effect of AmB on the reponses to sheep erythrocytes(SRBC) by footpad swelling reaction and rosette formation of spleen cells in ICR mice. DTH in AmB-treated mice (17.5㎎/㎏ per mouse) were generally increased compared to those of PBS-treated controls. The optimal immunopotentiating effect of AmB was provoked when the mouse was sensiitzed with SRBC at 10-fold higher doses of antigen (10^8SRBC/mouse) than those required for optimal immune response in PBS-treated control mice (10^7SRBC/mouse). DTH of AmB-treated mice were enhanced when AmB was injected into mice before or at the same time of SRBC-sensitization, particularly the enhancement degree of DTH was more prominent when mice were treated with AmB at the same time of sensitization than before. However, there was no significant difference in the response when AmB given after sensitization. The percentage of RFR was decreased compared with those of control when AmB was administrated before SRBC-sensitization, but was increased when AmB was treated after SRBC.

1996년도 학술 제 2분과(초음파)활동 보고

이승석,박익근 韓國非破壞檢査學會 1997 한국비파괴검사학회지 Vol.17 No.2

除草劑處理에 의한 簡易草地造成에 관한 硏究

李根常,尹益錫 건국대학교 1978 論文集 Vol.7 No.1

This study was conducted to investigate the effects of several herbicides under oversowing and the application methods of Gramoxone as well as effects of burning. These trials were established in 1974 on natural grassland in Che Ju where Miscanthus purpurascens and Imperata cylindrica are dominant and foil type is volcano ash. The results obtained from 3 years experimentation are summarized as follows. 1.Gramoxone, of immediate effect, and Round-up, of slow effect showed similiar effect of weed control and both herbicides did not affect on emergence and early growth of sown species. 2.In case of oversowing, herbicides application did not increase the total dry matter yield but the yield of sown species was increased significantly (P < 0.01). There were, however, no significant differences in grasses yield among different herbicides. 3.In the natural grassland where Miscanthus purpruascens and Imperata cylindrica were dominant, the optimal amounts of herbicides were 400cc in Gramoxone and 600cc in Round-up per 10 a when oversowing method was applied. 4.The times of herbicide application and burning of grassland before sowing did not affect on total dry matter yields, but burning helped emergence and establishment of the sown species compared to no burning. 5.When a pasture was established by oversowing the clover content was higher with herbicide application and increased with increasing rate of herbicides.

표면 SH파 모드의 분산특성 해석과 그 응용

이상용,박익근,윤종학,노승남,안형근 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

A new flaw detection technique using by SH angle beam method has been discussed. The SH-wave is horizontally polarized shear wave and the surface SH wave has a characteristic of traveling along near surface layer. The surface SH wave technique is valuable for the detection of fatigue cracks at fillet weld heels which cannot be detected by other ultrasonic technique such as angle beam technique and The dispersion curves of it has simple characterization. In this work, using these beneficial chraterization, quality evaluation of spot weld with ultrasonic sound intensity of SH-wave passing through nugget area of spot weld are verified experimentally.

양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여

지익성,신석철,왕성근,이선우,신용재,김충수,김상국,최하석,오승용,류택근,이영호 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

유도초음파를 이용한 2.25Cr-1Mo재의 열화도 평가

박익근,박은수,이상용,권숙인,조윤호,윤승현 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.4

고온에서 장시간 사용으로 인하여 발생되는 경년열화 평가에는 파괴적인 방법이 신뢰성이 높지만 시험편 채취의 어려움이 있다. 그러므로 비파괴적인 방법에 의한 열화도 평가가 바람직하다. 본 연구에서는 2.25Cr-1Mo강에 대하여 장시간 등온열처리로 모의 열화시험편을 제작하여 고온설비부재에서 발생되는 탄화물의 석출 및 조대화, 불순물의 입계편석 등 금속학적 미세조직을 관찰하고, 미세조직의 변화와 유도 초음파의 전파특성과의 상관관계를 규명하고, 파괴시험치와 그 결과를 비교하여 초음파 비파괴평가에 의한 고온부재의 열화도 평가의 가능성을 실험적으로 검증하고자 한다. The destructive method is reliable and widely used for the estimation of material degradation but, it have time-consuming and a great difficulty in preparing specimens from in-service industrial facilities. Therefore, the etimation of degraded structural materials by nondestructive evaluation is strongly desired. In this paper, the use of guided wave was suggested for the evaluation of thermally damaged 2.25Cr-1Mo steel as an alternative way to compensate for limitations of fracture tests. The observation of microstructure variations of the material including carbide precipitation increase and spheroidization near gain boundary was conducted and the correlation with the guided wave features such as energy loss ratio and group velocity changes was investigated. Through this study the feasibility of ultrasonic guided wave evaluation for thermally damaged materials was explored.

치료저항 정신분열병환자에서 Clozapine의 효과 및 안전성

지익성,김영희,신석철,왕성근,신윤오,이선우,김정란 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

In order to assess the efficacy and safety of clozapine, 50 in-patients with treatment-resistanat schizophrenia were evaluated using PANSS(Positive and Negative Symptome Scale for Schizophrenia), CGI(Clinical Global Impression), AMS(Abnormal Involuntary Movement Scale), Adverse Event-Somatic Symptoms, Neurological Rating Scale for EPS before and during treatment. Mean daily dosage of clozapine was 344.15±123.43mg at 12th week. A clinically significant improvement in positive, negative, and general psychopathology was noted as early as week 2 through 12 week. The tolerability of clozapine was generally found to be good. Drowsiness/sleepiness, Hypersalivation, and Constipation were the most common side effects. There was no neutropenia, and 3 patients suffered from seizures. These results suggest that clozapine is worth considering for the treatment-resistant patients

정신분열증에서 공존하는 신체질환에 대하여

지익성,왕성근,신석철,이선우,황선희,신용재,김정란,배경도 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

In order to determine the frequency of physical illness in schizophrenia, 107 schizophrenics were assessed with physical exam and routine laboratoy test. The results were as follows 1) Among the total number of 107 schizophrenics, 31 had the physical illness(29%), and among the schizophrenics with physical illness, female outnumbered male at the rate of 17:14. 2) There was no difference between schizophrenics with physical illness and schizophrenics without physical illness in demographic characteristics. 3) Classification of physical illness were disease of skin 7 (22.6%), musculoskeletal system 5(16. 1%), ENT(ear nose throat) 3(9.7%), endocrine system 3(9.7%), circulatory system 2(6.5%), respiratory system 2(6.5%), digestive system 1(3.2%), genitourinary system 1(3.2%), infection 1(3. 2%), eye 1(3.2%) respectively Authors suggest that physical exam and routine laboratory test should be done for all hospitalized psychiatric patients