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Lee, Sun Haeng,Kwak, Sung Chul,Kim, Dong Kwan,Park, Sang Woug,Kim, Hyun Soo,Kim, Young-Sik,Lee, Donghun,Lee, Ju Won,Lee, Chang Gon,Lee, Hae Kyung,Cho, Sung-Min,Shin, Yu Jeong,Lee, Jin Yong,Kim, Hocheo Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 <I>μ</I>g/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only), or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary.</P>
Lee, Donghun,Lee, Sung Hyun,Lee, Yoon Hee,Song, Jungbin,Kim, Hocheol Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>Astragalus extract mixture HT042 is a standardized ingredient of health functional food approved by Korean FDA with a claim of “height growth of children.” HT042 stimulates bone growth rate and increases local IGF-1 expression in growth plate of rats which can be considered as direct stimulation of GH and its paracrine/autocrine actions. However, it remains unclear whether HT042 stimulates circulatory IGF-1 which also plays a major role to stimulate bone growth. To determine the effects on circulatory IGF-1, IGF-1 and IGFBP-3 expressions and phosphorylation of JAK2/STAT5 were evaluated in the liver after 10 days of HT042 administration. HT042 upregulated liver IGF-1 and IGFBP-3 mRNA expression, IGF-1 protein expression, and phosphorylation of JAK2/STAT5. HT042 also increased bone growth rate and proliferative zonal height in growth plate. In conclusion, HT042 stimulates bone growth rate via increment of proliferative rate by upregulation of liver IGF-1 and IGFBP-3 mRNA followed by IGF-1 protein expression through phosphorylation of JAK2/STAT5, which can be regarded as normal functioning of GH-dependent endocrine pathway. </P>
이중선체 내의 용접작업을 위한 자율주행 형 메커니즘 개발 및 응용
이동훈(Donghun Lee),이성철(Sungcheul Lee),구남국(Namkuk Ku),하솔(Sol Ha),김종원(Jongwon Kim),이규열(Kyu-Yeul Lee),김태완(Taewan Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
The welding is very difficult and dangerous for manual welders. Especially double hull structure has very hazardous environment, so shipbuilding industry demands the autonomous system instead of manual welders. This paper describes design of a totally new designed mobile robot, called ‘Rail Runner’, for welding in a double hull structure. Due to the welding work involved in the assembly procedure of a double hull structure, this research addressed both the mechanical and control systems of the robot. The mechanical system of this robot is composed of six axes manipulator for welding function and six axes mobile platform for traveling in the double hull structure. This robot is able to autonomously travel and weld a U-shaped part in a double hull structure. The ‘Rail Runner’ can elevate the efficiency of the welding process against manual welders and the international competitiveness of the shipbuilding industry.
( Jong-hoon Lee ),( Donghun Shin ),( Bitnara Lee ),( Hyundong Lee ),( Inhyung Lee ),( Do-won Jeong ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.5
Eighty-five Enterococcus faecalis isolates collected from animals (40 isolates), meju (a Korean fermented soybean product; 27 isolates), humans (10 isolates), and various environmental samples (8 isolates) were subjected to multilocus sequence typing (MLST) to identify genetic differences between samples of different origins. MLST analysis resulted in 44 sequence types (STs), and the eBURST algorithm clustered the STs into 21 clonal complexes (CCs) and 17 singletons. The predominant STs, ST695 (21.1%, 18/85) and ST694 (9.4%, 8/85), were singletons, and only contained isolates originating from meju. None of the STs in the current study belonged to CC2 or CC9, which comprise clinical isolates with high levels of antibiotic resistance. The E. faecalis isolates showed the highest rates of resistance to tetracycline (32.9%), followed by erythromycin (9.4%) and vancomycin (2.4%). All isolates from meju were sensitive to these three antibiotics. Hence, MLST uncovered genetic diversity within E. faecalis, and clustering of the STs using eBURST revealed a correlation between the genotypes and origins of the isolates.
DongHun Lee,Hyun Lee,Hideto Imajo,Yuichi Yoshioka,Takeshi Kanashima,Masanori Okuyama 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.31
The electrical property of the interfacial layer is improved by fluorine treatment on HfO_2/Ge metal-insulator-semiconductor (MIS) device. The thin HfO_2 dielectric was prepared using a photo-assisted metal organic chemical vapor deposition (MOCVD) system. However, the fluorine was easily out-diffused after post metallization annealing (PMA) at high temperature. In this study, the post nitridation of the fluorinated HfO_2/Ge gate stack has been carried out by using nitrogen (N) radical treatment at high temperature (200˚C) to prevent the fluorine (F) diffusion. The interface traps such as poorly passivated dangling bonds and oxygen vacancies (V_0) near the interface were passivated by co-doping of F and N. Consequently, the dielectric property of HfO_2/Ge gate stack has been improved to hamper F out-diffusion. Therefore, it is suggested that N radical treatment following F_2-treatment is very useful solution for improving dielectric property of HfO_2/Ge gate stack.
Large Electroabsorption Susceptibility Mediated by Internal Photoconductive Gain in Ge Nanowires
Lee, Hyun-Seung,Kim, Cheol-Joo,Lee, Donghun,Lee, Ru Ri,Kang, Kibum,Hwang, Inchan,Jo, Moon-Ho American Chemical Society 2012 NANO LETTERS Vol.12 No.11
<P>Large spectral modulation in the photon-to-electron conversion near the absorption band-edge of a semiconductor by an applied electrical field can be a basis for efficient electro-optical modulators. This electro-absorption effect in Group IV semiconductors is, however, inherently weak, and this poses the technological challenges for their electro-photonic integration. Here we report unprecedentedly large electro-absorption susceptibility at the direct band-edge of intrinsic Ge nanowire (NW) photodetectors, which is strongly diameter-dependent. We provide evidence that the large spectral shift at the 1.55 μm wavelength, enhanced up to 20 times larger than Ge bulk crystals, is attributed to the internal Franz–Keldysh effect across the NW surface field of ∼10<SUP>5</SUP> V/cm, mediated by the strong photoconductive gain. This classical size-effect operating at the nanometer scale is universal, regardless of the choice of materials, and thus suggests general implications for the monolithic integration of Group IV photonic circuits.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-11/nl3033203/production/images/medium/nl-2012-033203_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl3033203'>ACS Electronic Supporting Info</A></P>
Spatially Resolved Photodetection in Leaky Ferroelectric BiFeO<sub>3</sub>
Lee, Won‐,Mo,Sung, Ji Ho,Chu, Kanghyun,Moya, Xavier,Lee, Donghun,Kim, Cheol‐,Joo,Mathur, Neil D.,Cheong, S.‐,W.,Yang, C.‐,H.,Jo, Moon‐,Ho WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.10
<P><B>Potential gradients due to the spontaneous polarization of BiFeO<SUB>3</SUB></B> yield asymmetric and nonlinear photocarrier dynamics. Photocurrent direction is determined by local ferroelectric domain orientation, whereas magnitude is spectrally centered around charged domain walls that are associated with oxygen vacancy migration. Photodetection can be electrically controlled by manipulating ferroelectric domain configurations.</P>
Perspectives on deterministic control of quantum point defects by scanned probes
Lee, Donghun,Gupta, Jay A. De Gruyter 2019 Nanophotonics Vol.8 No.11
<P><B>Abstract</B></P><P>Control over individual point defects in solid-state systems is becoming increasingly important, not only for current semiconductor industries but also for next generation quantum information science and technologies. To realize the potential of these defects for scalable and high-performance quantum applications, precise placement of defects and defect clusters at the nanoscale is required, along with improved control over the nanoscale local environment to minimize decoherence. These requirements are met using scanned probe microscopy in silicon and III-V semiconductors, which suggests the extension to hosts for quantum point defects such as diamond, silicon carbide, and hexagonal boron nitride is feasible. Here we provide a perspective on the principal challenges toward this end, and new opportunities afforded by the integration of scanned probes with optical and magnetic resonance techniques.</P>