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부자 추출물에 의한 인체 간암세포의Apoptosis 유도에 관한 연구
임동진,최영현,황원덕 대한암예방학회 2008 Journal of cancer prevention Vol.13 No.2
Aconiti tuber has been used in oriental herbal medicine since ancient times for analgesic, anti-rheumatic and neurological indications. In the present study, it was investigated the biochemical mechanisms of anti-proliferative effects by the methanol extract of A. Tuber (MEBJ) in HepG2 and Hep3B human hepatocarcinoma cells. It was found that MEBJ could inhibit the cell proliferation of HepG2 and Hep3B cells in a concentration-dependent manner, which was associated with induction of apoptotic cell death such as formation of apoptotic bodies and increased populations of apoptotic-sub G1 phase. However, Hep3B cell treated with MEBJ reduced cell viability and induced apoptosis significantly more than in HepG2 cells. Apoptosis of Hep3B cells by MEBJ was connected with an up-regulation of pro-apoptotic Bax expression and a down-regulation of anti-apoptotic Bcl-2 and Bcl-xL in a dose-dependent manner. MEBJ treatment up-regulated the levels of Fas mRNA and protein, and the expression levels of IAPs family members such as cIAP-1 and cIAP-2 were down-regulated by MEBJ treatment. In addition, MEBJ treatment induced the proteolytic activation of caspase-3 and a concomitant degradation of poly (ADP-ribose) polymerase protein. Though further studies will be needed to identify the active compounds and mechanisms that confer the anti-cancer activity of MEBJ, these findings suggest that MEBJ may be a potential chemotherapeutic agent for the control of human cancer cells. (Cancer Prev Res 13, 142-152, 2008)
The Usefulness of Sagittal Reformation for Diagnosis of Sternal Fracture
임동진,한석,김영주 대한영상의학회 2014 대한영상의학회지 Vol.70 No.1
Purpose: The purpose of our study was to evaluate the usefulness of sagittal reformation of chest computed tomography for the diagnosis of sternal fracture after trauma. Materials and Methods: We retrospectively reviewed medical records and chest computer tomography (CT) of 716 patients in the emergency department after trauma between January and December 2010. Two radiologists investigated chest CT images. We investigated numbers and locations of sternal fractures on axial images only and on both axial and sagittal images for each radiologist. Results: First, radiologist found sternal fractures in 58 patients (70.7%) on only axial images, and 80 (97.5%) on both axial and sagittal images. Second, radiologist found fractures in 67 patients (81.7%) on axial image only and 81 (98.7%) on both axial and sagittal images. The sensitivity increased after adding sagittal reformation images for each radiologist (p < 0.05, respectively). On the axial images, the interobserver agreement was low (κ = 0.596) between the two radiologists. However, on both axial and sagittal images, the interobserver agreement increased (κ = 0.872). Conclusion: Sagittal reformation of chest CT increases the chance of diagnosis for sternal fracture and leads to early diagnosis resulting in appropriate treatment.
Carbon-based drug delivery carriers for cancer therapy
임동진,심명부,오이슬,임경희,박한수 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
In the search to improve anticancer therapies,several drug carriers, including carbon-based nanomaterialshave been studied. Both liposomes and polymericmicrospheres have been used in anticancer drugs. However,there remains an on-going need for better therapeuticmaterials that have good drug solubility, an ability toreduce systemic toxicity through specific-tumor targeting,and rapid clearance. In this regard, carbon allotropes suchas graphene oxide (GOs), carbon nanotubes (CNTs), andnanodiamonds (NDs), have been investigated, as theypossess sufficient surface-to-volume ratio, thermal conductivity,rigid structural properties capable of postchemicalmodification, and excellent biocompatibility. This review is aimed at exploring these carbon-basednanomaterials for use as multifaceted cancer drug carriersand is intended to demonstrate that GOs, CNTs, and NDsare likely to improve chemotherapeutical strategy forcancers in either a sole or combinational manner.
임동진,박한수,심명부,허윤회,전호욱 한국고분자학회 2015 Macromolecular Research Vol.23 No.12
Electrospinning is a technique that has been widely utilized to create nanofibrous scaffolds that mimic the cellular environment. Scaffold fabrication using the conventional electrospinning technique is cost-effective and simple. However, this method is slightly problematic in terms of creating a well-defined structure. To create a uniformly patterned and porous nanofibrous scaffold, in this study, we utilized an easy module consisting of a patterned watersoluble film placed on the top of a conventional collector. Scaffolds fabricated with either poly(lactide-co-glycolide) (PLGA) or poly(ε-caprolactone) (PCL) were seeded with human adipose-derived stem cells (hASCs), and evaluated for cellular proliferation. The patterned and porous nanofibrous scaffolds facilitated significantly better hASC proliferation compared to scaffolds prepared using a conventional collector apparatus. Enhanced hASC proliferation was confirmed by total cellular proliferation activity evaluation and scanning electron microscopy (SEM). These results indicate that the facile method described in this study would be promising for preparation of patterned and porous nanofibrous scaffolds for a variety of tissue engineering applications.