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최은미,Yan Ding,Huu Tung Nguyen,박상혁,Xuan Nhiem Nguyen,Chun Liang,이정준,김영호 한국생약학회 2008 Natural Product Sciences Vol.14 No.1
The leaves of Acanthopanax species have traditionally been used as a tonic and a sedative as well as in the treatment of rheumatism and diabetes. Chiisanoside is the major active lupane triterpenoid of Acanthopanax leaves. To investigate the bioactivities of chiisanoside, which act on bone metabolism, the effects of chiisanoside on the function of osteoblastic MC3T3-E1 cells were studied. Chiisanoside (0.02~20 μM) significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and nodules mineralization in the cells (P < 0.05). The effect of chiisanoside (2 μM) in increasing ALP activity was completely prevented by the presence of tamoxifen, suggesting that the effect of chiisanoside might be partly estrogen receptor mediated. Moreover, cotreatment of p38 inhibitor SB203580 or JNK inhibitor SP600125 inhibited chiisanoside-mediated ALP upregulation, suggesting that the induction of differentiation by chiisanoside is associated with increased activation of p38 and JNK mitogen-activated protein kinases. Our data indicate that the enhancement of osteoblast function by chiisanoside may result in the prevention for osteoporosis.
Won, Jong-Heon,Park, Sang-Yong,Nam, Sang-Gil,Park, Hee-Juhn,Choi, Jung-Won,Lee, Kyung-Tae EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
In the present study, the effects of several triterpenes isolated from the leaves of Acanthopanax chiisanensis (Araliaceae), namely, chiisanoside, isochiisanoside, 22-hydroxychiisanoside and chiisanogenia (the aglycone of chiisanoside) were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) and (prostaglandin E_(2) (PGE_(2)) production by the RAW 264.7 macrophage cell line, Of the triterpenes tested, chiisanoside was found to most potently inhibit NO and PGE_(2) production. In addition, chiisanoside significantly reduced the release of in flammatory cytokines like TNF-α and IL-1β. Consistent with these observations, the protein and mRNA expression levels of iNOS and COX-2 enzyme were found to be inhibited by chiisanoside in a concentration-dependent manner. Furthermore, chiisanoside inhibited the nuclear factor-κB (NF-κB) activation induced by LPS and this was associated with a reduction in p65 protein in the nucleus and with the phosphorylations of ERK1/2 and JNK MAP kinases. Taken together, our data indicate that the anti-inflammatory properties of chiisanoside might be the result from the inhibition of iNOS, COX-2, TNF-α AND IL-1β expression through the down-regulation of NF-κB binding activity.
Chang Eui Hong,Seung Yeon Han,Hwan Gyu Kim,Su Yun Lyu 대한약학회 2017 약학회지 Vol.61 No.6
Acanthopanax species (Araliaceae) is used traditionally in Korea, Japan, and China, and is known for its ginsenglike activities and among them, Acanthopanax chiisanensis Nakai is one of the most abundant. In this study, we investigated the effects of chiisanoside and chiisanogenin isolated from A. chiisanensis on the secretion of interleukin (IL)-2, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) by human lymphocyte cell line U937. Our results show an increase in Th1 cytokine (IL-2, IL-12, TNF-α, and IFN-γ) secretion which suggests that chiisanogenin and chiisanoside from A. chiisanensis may influence the immune response towards a predominance of Th1 cytokines in the immune system. Further studies on Th2 cytokine secretion may be needed to confirm this conclusion.
Lee, Jeong-Min,Kim, Min-Hye,Lee, Sang-Hyun The Plant Resources Society of Korea 2007 한국자원식물학회지 Vol.20 No.3
High performance liquid chromatography (HPLC) was used for the analysis of chiisanoside in each stem and root of Acanthopanax senticosus collected from South Korea, North Korea, China and Russia. A reverse-phase system using a gradient of H$_{2}$O and acetonitrile as the mobile phase was developed and detection was at 210nm. The analysis was successfully carried out within 30 min. Chiisanoside was measured in the stem and root of A. senticosus collected from various countries.
Quantitative Analysis of Chiisanoside in Acanthopanax Species by HPLC
Jeong Min Lee,Hye Min Kim,이상현 한국생약학회 2007 Natural Product Sciences Vol.13 No.2
performance liquid chromatography (HPLC) was used for the analysis of chiisanoside inAcanthopanax species. A reverse-phase system using a gradient of H2O and acetonitrile as the mobile phase wasChiisanoside was measured in the fruit, stem and root of A. sessiliflorus, A. koreanus, A. divaricatus and A.senticosus.KeywordsAcanthopanax species, Araliaceae, chiisanoside, HPLC
Antibacterial Compounds from the Leaves of Acanthopanax senticosus
Lee, Sang-Hyun,Shin, Dong-Sun,Oh, Ki-Bong,Shin, Kuk-Hyun The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.1
Chiisanogenin (1), hyperin (2) and chiisanoside (3) were isolated from the leaves of Acanthopanax senticosus, and were tested for their inhibitory activities against 6 strains of bacteria. Among them, chiisanogenin (1) revealed broad but moderate antibacterial activities against G(+) and G(-) bacteria, the minimum inhibitory concentration (MIC) being in the range of 50-100 $\mu\textrm{g}$/ml.
박유선,함인혜,황완균 중앙대학교 약학연구소 1997 약학 논총 Vol.11 No.-
Constituents from the leaves of Acanthopanax senticosus var. Koreanus(Araliaceae), a plant origin of Acanthopanax senticosi Cortex which has been used as tonic, stress-relaxing agent, antidiabetes, antirheumatic, etc. in Korean folk medicine were isolated. The methanolic extracts of dried leaves of Acanthopanax senticosus var. Koreanus was suspended in ether to remove fatty substances. The aqueous fraction was further seperated by Amberlite XAD-2 column employing gradient solvent systems(H_2O, 20, 40, 60, 100% MeOH). By successive column chromatography using sephadex LH-20, ODS and polasil gel. Compound Ⅰ and Cpmpound Ⅱ, were isolated from the 40% MeOH fraction. Chemical structures of Compound Ⅰ and Ⅱ were identified as chiisanoside, and quercetin-3-β-D-galactopyranoside respectively on the basis of physico-chemical and spectral data of IR, FAB-MS, ^1H-NMR, ^13C-NMR, ^1H-^1H COSY, ^13C-^1H COSY and HMBC(^1H-Derected Multiple-bonded Heteronuclear quantum Coherence spectrum).
조형권(Hyoung Kwon Cho),함인혜(In Hye Ham),황완균(Wan Kyunn Whang) 대한약학회 1999 약학회지 Vol.43 No.3
From the water fraction of the MeOH extract, three compounds, 1,3,4,5-terrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate) (chlorogenic acid), quercetin 3-O-beta-D-galactopyranoside (hyperoside), and 1(R)-hydroxy-3,4-seco-lup-4(23),20(30)-dien-3,11alpha-olactone-1apha-L-rhamnopyranosyl(1->4)-beta-D-glucopyranosyl(1->6)-beta-L-glucopyranosyl ester (chiisanoside) were isolated and their strutures determinated by 1H-NMR, 13C-NMR, IR, and FAB-Nass. Chlorogenic acid and Chiisanoside had been quantitated by HPLC from eight Acanthopanax species per 10g A. koreanum 19.82, 4.17mg, A. nambunensis 65.00, 1.86mg, A chiisanense 67.19, 4.72mg, A. albeofructus 69.58, 4.96mg, A. chungbunensis 31.96, 6.73mg, A. pedunclus 13.95, 1.52mg, A. senticosus 27.19, 8.17mg, A. sessiliflorum 7.49, 5.88mg.
Lupane계 Triterpenoid류가 임파구 분열에 미치는 효과
김영옥(Young Ok Kim),조대현(Dae Hyun Cho),정혜주(Hye Joo Chung),김진호(Jin Ho Kim),장승엽(Seung Yeup Chang),육창수(Chang Soo Yook),양기숙(Ki Sook Yang),오오진(O Jin Oh) 대한약학회 1999 약학회지 Vol.43 No.2
The effects of five lupane-triterpenoids from leaves of two Acanthopanax spp., chiisanogenin, chisanoside and 22alpha-hydroxychiisanogenin, acakoreoside A and acantrifoside A on the mitogen-induced proliferation were investigated in vitro. T cell proliferation (TCP) to concanavalin A (Con A) and the B cell proliferation (BCP) to lipopolysaccharide (LPS) were increased by chiisanogenin. TCP to Con A was significantly increased by chiisanoside and acankoreoside A, but not affected by chiisanogenin, 22 alpha-hydroxychiisanogenin and acantrifoside A, BCP to LPS was significantly increased by acankoreoside A and acantrifoside A, and slightly increased by chiisanoside, chiisanogenin and 22 alpha-hydroxychiisanogenin.
안혜정(Hye Jung An),육창수(Chang Soo Yook),김형춘(Hyoung Chun Kim),고성권(Sung Kwon Ko) 대한약학회 2017 약학회지 Vol.61 No.2
This study was carried out to obtain the basic information that can be used to index Acanthopanax in ten species of China and Korea. The phytochemical components from the leaf of Acanthopanax species, were measured by the HPLC analysis. Protocatechuic acid, eleutheroside B, eleutheroside E, scopolin, rutin, hyperoside, chiisanoside, oleanolic acid were found in ethanol extracts from the leaf of Acanthopanax species. Total phenolic compound of Acanthopanax sieboldianum leaf (2.499%) was about 5.7 times higher than those of Acanthopanax divaricatus f. flavi-flos leaf (0.436%). As a result, the order of the rutin content was 1) A. sieboldianum (2.019%), 2) A. gracillstylus (1.087%), 3) A. seoulense (0.073%). On the other hand, total terpenoid of Acanthopanax divaricatus leaf (9.602%) from Korea was about 24 times higher than those of A. gracillstylus leaf (0.400%) from China. And also, the order of the chiisanoside content was 1) A. divaricatus (9.190%), 2) A. senticosus var. subinermis (8.767%), 3) A. divaricatus f. distigmatis (8.743%).