Profile of chronic and aggressive periodontitis among Senegalese

Benoist, Henri Michel,Seck-Diallo, Adam,Diouf, Abdoulaye,Yabbre, Salama,Sembene, Malick,Diallo, Papa Demba Korean Academy of Periodontology 2011 Journal of Periodontal & Implant Science Vol.41 No.6

Purpose: To describe the profile of chronic and aggressive periodontitis among Senegalese (West Africans) attending the Institute of Dentistry of Dakar. Methods: A retrospective study was conducted with an inclusion period running from 2001 to 2008. The sample included 413 chronic periodontitis and 151 aggressive periodontitis cases, among them 299 males and 265 females selected from 2,274 records. A Student's independent t-test or Pearson chi-squared test was used for data analysis. Results: The proportion of females with aggressive periodontitis was significantly higher than those with chronic periodontitis (64.9% vs. 40.4%, P<0.001). The aggressive periodontitis patients had an average age of $28.1{\pm}8.9$ years, and had lost less than 3 teeth. Less than a third of them reported using a toothbrush. Attachment loss was as high as 8 mm and severe lesions had spread to an average of 12 teeth with maximum alveolar bone loss up to 80%. The chronic periodontitis patients had an average age of $44.9{\pm}14.0$ and had lost on average less than 3 teeth. Nearly 75% used a toothbrush. Attachment loss was significantly higher and lesions were more extensive in the aggressive periodontitis. Chronic periodontitis is associated with risk factors such as smoking or diabetes mellitus in 12.8% versus 0.7% in aggressive periodontitis (P<0.001). Differences between the two groups for most clinical and radiographic parameters were statistically significant. Conclusions: The profile of aggressive periodontist is characterized by more severe lesions than chronic periodontitis, whereas tooth loss experience is similar in both forms.

Profile of chronic and aggressive periodontitis among Senegalese

Henri Michel Benoist,Adam Seck-Diallo,Abdoulaye Diouf,Salama Yabbre,Malick Sembene,Papa Demba Diallo 대한치주과학회 2011 Journal of Periodontal & Implant Science Vol.41 No.6

Purpose: To describe the profile of chronic and aggressive periodontitis among Senegalese (West Africans) attending the Institute of Dentistry of Dakar. Methods: A retrospective study was conducted with an inclusion period running from 2001 to 2008. The sample included 413chronic periodontitis and 151 aggressive periodontitis cases, among them 299 males and 265 females selected from 2,274 records. A Student’s independent t-test or Pearson chi-squared test was used for data analysis. Results: The proportion of females with aggressive periodontitis was significantly higher than those with chronic periodontitis (64.9% vs. 40.4%, P<0.001). The aggressive periodontitis patients had an average age of 28.1±8.9 years, and had lost less than 3 teeth. Less than a third of them reported using a toothbrush. Attachment loss was as high as 8 mm and severe lesions had spread to an average of 12 teeth with maximum alveolar bone loss up to 80%. The chronic periodontitis patients had an average age of 44.9±14.0 and had lost on average less than 3 teeth. Nearly 75% used a toothbrush. Attachment loss was significantly higher and lesions were more extensive in the aggressive periodontitis. Chronic periodontitis is associated with risk factors such as smoking or diabetes mellitus in 12.8% versus 0.7% in aggressive periodontitis (P<0.001). Differences between the two groups for most clinical and radiographic parameters were statistically significant. Conclusions: The profile of aggressive periodontist is characterized by more severe lesions than chronic periodontitis, whereas tooth loss experience is similar in both forms.

Outcomes of nonsurgical periodontal therapy in severe generalized aggressive periodontitis

Amal Bouziane,Latifa Benrachadi,Redouane Abouqal,Oumkeltoum Ennibi 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.4

Purpose: Aggressive periodontitis, especially in its severe form, was traditionally considered to have an unfavourable prognosis. It required a complex treatment and its stabilization was often achieved by surgical therapy. The aim of this study was to investigate the results of nonsurgical periodontal treatment in severe generalized forms of aggressive periodontitis. Methods: Patients with advanced generalized aggressive periodontitis were included in the study. Probing depth (PD) of pockets ≥7 mm and clinical attachment level (CAL) of sites with attachment loss ≥5 mm were measured at baseline before nonsurgical periodontal treatment, at re-evaluation, and after treatment. The following other parameters were recorded: resolution of inflammation and bone fill. We compared the baseline values with re-evaluation and posttreatment values using the Friedman test. The Wilcoxon test with the Bonferroni correction was used for both re-evaluation and posttreatment values. Results: Seven patients with 266 periodontal sites were examined. A significant difference was found between values, reported as medians with interquartile ranges, for PD at baseline (7.94 [7.33–8.19] mm) and both re-evaluation (4.33 [3.63–5.08] mm) and posttreatment (3.54 [3.33–4.11] mm) values (P=0.002). A significant difference was also found between values for CAL at baseline (9.02 [7.5–9.2] mm) and both re-evaluation (6.55 [6.30–6.87] mm) and posttreatment (6.45 [5.70–6.61] mm) (P=0.002). Inflammation was resolved and angular bone defects were repaired in all cases. Conclusions: These therapeutic results suggest that this form of periodontitis could have positive outcomes after nonsurgical periodontal treatment. The reparative potential of tissue affected by severe aggressive periodontitis should encourage clinicians to save apparently hopeless teeth in cases of this form of periodontitis.

Outcomes of nonsurgical periodontal therapy in severe generalized aggressive periodontitis

Bouziane, Amal,Benrachadi, Latifa,Abouqal, Redouane,Ennibi, Oumkeltoum Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.4

Purpose: Aggressive periodontitis, especially in its severe form, was traditionally considered to have an unfavourable prognosis. It required a complex treatment and its stabilization was often achieved by surgical therapy. The aim of this study was to investigate the results of nonsurgical periodontal treatment in severe generalized forms of aggressive periodontitis. Methods: Patients with advanced generalized aggressive periodontitis were included in the study. Probing depth (PD) of pockets ${\geq}7mm$ and clinical attachment level (CAL) of sites with attachment loss ${\geq}5mm$ were measured at baseline before nonsurgical periodontal treatment, at re-evaluation, and after treatment. The following other parameters were recorded: resolution of inflammation and bone fill. We compared the baseline values with re-evaluation and posttreatment values using the Friedman test. The Wilcoxon test with the Bonferroni correction was used for both re-evaluation and posttreatment values. Results: Seven patients with 266 periodontal sites were examined. A significant difference was found between values, reported as medians with interquartile ranges, for PD at baseline (7.94 [7.33-8.19] mm) and both re-evaluation (4.33 [3.63-5.08] mm) and posttreatment (3.54 [3.33-4.11] mm) values (P=0.002). A significant difference was also found between values for CAL at baseline (9.02 [7.5-9.2] mm) and both re-evaluation (6.55 [6.30-6.87] mm) and posttreatment (6.45 [5.70-6.61] mm) (P=0.002). Inflammation was resolved and angular bone defects were repaired in all cases. Conclusions: These therapeutic results suggest that this form of periodontitis could have positive outcomes after nonsurgical periodontal treatment. The reparative potential of tissue affected by severe aggressive periodontitis should encourage clinicians to save apparently hopeless teeth in cases of this form of periodontitis.

한국인 급진성 치주염 환자의 치아상실 및 부착상실 평가에 관한 연구

정영미 ( Young Mi Chung ),정성념 ( Seong Nyum Jeong ) 조선대학교 치의학연구원 2013 Oral Biology Research (Oral Biol Res) Vol.37 No.1

The aim of this study was to assess the prevalence of aggressive periodontitis as well as tooth loss and periodontal attachment loss in subjects who visited the Department of Periodontology of Wonkwang University Daejeon Dental Hospital. Materials and Methods: A total of 3,284 patients with periodontitis from January 2010 to June 2012 were included in this study. We investigated prevalence of periodontitis, age, gender, and clinical parameters (probing depth, gingival recession, tooth loss, periodontal attachment loss), and radiographic examination was performed at the baseline. Results: Sixty-six (2.01%) patients showed clinical features of aggressive periodontitis. Periodontal attachment loss of the maxillary first molar was 0.85 mm, which was the highest. The average number of missing teeth was 1.35 per subject. Tooth mortality was the highest at the maxillary first molar and at the mandibular second molar. Conclusion: Within the limitations of this study, periodontal breakdown as evaluated by attachment loss was the most severe at the first molars of aggressive periodontitis patients. It is important to recognize clinical features of aggressive periodontitis for proper diagnosis and determination of treatment timing. Further studies are needed to obtain more precise epidemiologic information, including the prevalence of aggressive periodontitis in Koreans, and investigate the potential roles of risk factors and contributory factors, such as root abnormality, occlusion, family aggregation, gene polymorphism, and Herpes virus infections.

만성 치주염과 급속 파괴성 치주염에서의 흑색색소 형성 Bacteroides의 분포도 비교

신철우,최봉규,문익상,김종관,조규성,Shin, Chul-Woo,Choi, Bong-Kyu,Moon, Ik-Sang,Kim, Chong-Kwan,Cho, Kyoo-Sung 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2

The purpose of the research is to compare the distribution of Black-pigmented Bacteroides between Chronic Periodontitis and Aggressive Periodontitis. P. gingivalis, P. intermedia and P. nigrescens were examined in order to evaluate their distribution in patients with Chronic Periodontitis(CP) and Aggressive Periodontitis(AP). PCR and dot-blots hybridization of 16s rRNA gene were used to compare bacterial distribution of two groups - CP group and AP group, which were divided into two subgroups. Subgingival plaque taken from the diseased sites(pocket $depth{\geq}6$ mm) and healthy sites(pocket $depth{\leq}3$ mm) were grouped into the experimental group and the control group. The result are as follows ; 1. The distribution of P. gingivalis was 98.33% for chronic Periodotitis(CP), 94.17% for Aggressive Periodontitis(AP), the distribution of P. intermedia was 77.50% for CP, 64.17% for AP, and the distribution of P. nigrescens was 35.00%, 29.17%. In all 3 types of bacteria, CP group showed higher distribution compared to AP group, but only P. intermedia showed statistically significant difference. 2. In the case of CP, every type of bacteria showed higher distribution in the experimental group with statistically significant difference. 3. In the case of AP, every type of bacteria also showed higher distribution in the experimental group, but P. gingivalis and p..intermedia showed the result with statistically significant difference, and the other did not 4. In 3 all bacteria type, N-AP showed higher distribution than N-CP without statistically significant difference These results suggest that the comparison of the distribution of Bacteroides between Chronic Periodontitis and Aggressive Periodontitis has no statistically significant difference, except P. intermedia.

급진성 치주염 환자에서 전신적 항생제 복용을 동반한 외과적 치주 치료 후 치주조직의 재생: 증례보고

임상진 ( Sang Jin Lim ),윤우혁 ( Woo Hyuk Yun ),피성희 ( Sung Hee Pi ),유형근 ( Hyung Keun You ) 조선대학교 구강생물학연구소 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.2

The purpose of this study is to evaluate the feasibility of periodontal tissue regeneration in patients suffering from aggressive periodontitis who took systemic antibiotics as an adjunctive to periodontal treatment. Two patients with aggressive periodontitis were selected. Examination of clinical value and radiograph were performed. First, they took scaling and root-planing with systemic antibiotics. Appropriate surgical treatments were followed with selective alveolar bone graft. Patients visited regularly for postoperative clinical and radiographic evaluations. After periodontal treatment with an adjunctive antibiotics, improved clinical index such as increased clinical attachment level, decreased mobility and bleeding on probing were found in comparison with initial examination. Recovery of bone loss was observed in radiographic examination. This study suggests that periodontal treatment with systemic antibiotics is effective on prevention of disease and regeneration of periodontal tissue in patients with aggressive periodontitis.

Inverse behavior of IL-23R and IL-17RA in chronic and aggressive periodontitis

Ruiz-Gutierrez, Alondra del Carmen,Rodriguez-Montano, Ruth,Pita-Lopez, Maria Luisa,Zamora-Perez, Ana Lourdes,Guerrero-Velazquez, Celia Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.4

Purpose: Periodontitis is associated with a dysbiosis of periodontopathic bacteria, which stimulate the interleukin (IL)-23/IL-17 axis that plays an essential role in the immunopathogenesis of this disease, leading to alveolar bone destruction through receptor activator of nuclear factor κB ligand (RANKL). IL-23 receptor mRNA (IL-23R) has been identified in periodontitis, and IL-17 receptor A mRNA (IL-17RA) and its protein have not yet been evaluated in patients with periodontitis. In this study was measure IL-23R and IL-17RA in gingival tissue (GT) from patients with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAP) and to explore correlations with clinical parameters. Methods: We included 16 healthy subjects (HS), 18 patients with GCP, and 14 with GAP. GT samples were collected during periodontal surgery. Both IL-23R and IL-17RA were detected by enzyme-linked immunosorbent assay. Results: The results were analyzed with Mann-Whitney U test and Spearman' rank correlation coefficients using SPSS version 25.0. We found lower IL-23R levels in patients with GCP and GAP than in HS. Contrarily, we observed higher IL-17RA levels in GCP and GAP patients than in HS. Moreover, we found negative correlations between IL-23R in GT and probing depth and clinical attachment loss (CAL). Likewise, a positive correlation of IL-17RA in GT with CAL was found. Conclusions: The results of these findings suggest that the reverse behavior between IL-23R and IL-17RA in periodontitis patients may also be involved with the activation of RANKL, which promotes alveolar bone loss.

한국인 전반적 급진성 치주염 환자에서 IL-10 promoter 유전자 다변성에 관한 연구

류지선,김옥수,Ryn, Ji-Sun,Kim, Ok-Su 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.3

Genetic polymorphisms associated with aggressive periodontitis have previously been reported. Interleukin-10 is an immunoregulatory cytokine that plays a role in the pathogenesis of periodontitis. Individual capacity for IL-10 production appears to be under genetic influence, The aim of present investigation was to explore possible genetic association of IL-10 gene promoter polymorphisms with generalized aggressive periodontitis. The study population consisted of 37 generalized aggressive periodontitis patients from the Department of Periodontology, Chonnam National University Hospital and 27 control subjects, all the subjects were non-smokers, Genomic DNA was obtained from buccal swab. The IL-10promoter -597, -824, -1082 positions were genotyped by amplifying the polymorphic regions using polymerase chain reaction (PCR) , followed by restriction enzyme digestion and gel electrophoresis. IL-10-597 C (allele 1) to A (allele 2) and IL-10-824 C (allele 1) to T (allele 2) and IL-10-1082 G (allele 1) to A (allele 2) polymorphisms were examined. The results were as follows. 1. In patients, the distribution of genotypes C/C, C/A and NA at Il-10-597 was determined to be 13.5%, 37.8% and 48.7%, respectively and the distribution of genotypes at IL-10-824 was the same as that of IL-10-597. The distribution of genotypes G/G, G/A and NA at IL-10-1082 was found to be 2.7%, 16.2% and 81. 4%, respectively. No statistical difference in genotype distribution was found between the patient and control groups. 2. Allele 2 carriage rate at the three position of the IL-10 promoter region was higher in the control group than the patient group. 3. Allele 2 frequencies at IL-10-597 and -824 positions were higher in female group than male group and its difference was statistically significant(p<0.05). No significant difference in genotype distribution between the control and patient groups. Allele frequency between control and patient groups was not significantly different although allele 2 frequency at the three positions in the IL-10 promoter region appeared to be higher in control group. In conclusion, no clear association between IL-10 gene promoter polymorphisms and generalized aggressive periodontitis in Korean was observed.

와타나베이닦기법을 이용한 급진성치주염 환자의 주기적 구강건강관리 증례

조부덕 ( Boo Deok Jo ),정성국 ( Seong Kug Jeong ),이금호 ( Keum Ho Lee ),김아현 ( Ah Hyun Kim ),이병진 ( Byoung Jin Lee ),김동기 ( Dong Kie Kim ) 대한구강보건학회 2012 大韓口腔保健學會誌 Vol.36 No.4

Objectives: The purpose of this study was to evaluate the effect of regular oral health care using Watanabe`s tooth brushing method on aggressive periodontitis. Methods: A 14-year-old female visited our clinic with the chief complaint of gingival swelling and teeth mobility in 2008. The present illness on the day of visit was gingivitis with swelling and redness on marginal gingiva, root exposure due to the attachment loss and gingival recession and the degree 3 mobility of #26, 36, 46 with no systemic disease and familial tendency, The panoramic radiograph showed the severe vertical and horizontal alveolar bone loss in the first molars. For the treatment, preventive care including tooth brushing instruction and professional tooth brushing using Watanabe`s method and periodontal treatment using scaling and root planing, plaque control and antibiotics prescription were performed from the July, 2008 to September, 2012. Results: The patient could maintain all of her teeth without extraction except for one molar during the treatment period and symptoms of gingivitis decreased all over the oral region. But dental plaque level was not decreased. Conclusions: The regular oral health care with professional toothbrushing by Watanabe`s method was effective in relieving the gingival inflammation of patients with aggressive periodontitis.